Reichart E, Desplechain C, Foliguet B, Huyen V G
Unité de Physiopathologie Respiratoire INSERM U 14, CHU, Vandoeuvre-les-Nancy, France.
Exp Biol. 1988;47(3):145-50.
Subpleural emphysema induction was attempted by injecting elastase intrapleurally into rats and cats. Microscopic evaluation of emphysema (alveolar dilation and septal rupture) was compared with a quantification of alveolar dilation (Fawell-Newman method). The emphysema found in animals treated with an intrapleural injection of porcine pancreatic elastase did not appear to be specifically located in a subpleural zone, and was identical to the focal emphysema induced by an enzyme instillation into the airways. It should be noted that a placebo instillation into the feline airways sometimes induced alveolar dilation without septal disruption presumably by causing bacterial contamination. Cats were seen to be very sensitive to pleural stress since this enzyme injection produced an alveolar dilation (increased mean intercept) as significant as that in cats treated by an intrabronchial instillation of elastase (P less than 0.001).
通过向大鼠和猫的胸膜腔内注射弹性蛋白酶来尝试诱导胸膜下肺气肿。将肺气肿的微观评估（肺泡扩张和间隔破裂）与肺泡扩张的量化（Fawell - Newman方法）进行比较。经胸膜腔内注射猪胰弹性蛋白酶治疗的动物中发现的肺气肿似乎并非特异性地位于胸膜下区域，并且与通过气道内滴注酶诱导的局灶性肺气肿相同。应当注意，向猫气道内滴注安慰剂有时会导致肺泡扩张但无间隔破坏，推测是由于细菌污染所致。猫对胸膜应激非常敏感，因为这种酶注射所产生的肺泡扩张（平均截距增加）与经支气管内滴注弹性蛋白酶治疗的猫一样显著（P小于0.001）。
