Oláh I, Antoni F, Bánfalvi G, Csuka I, Luat N G, Töró I
2nd Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Dev Comp Immunol. 1988 Spring;12(2):385-95. doi: 10.1016/0145-305x(88)90013-4.
The effect of emetine which is a potent immunosuppresant was studied on the thymus and lymph node. The subcapsular zone of the thymus was depleted and large number of adherent cells accumulated in this thymic region. The medulla enlarged but the cortico-medullary border remained distinct. In the paracortex (T dependent area) of the lymph node many non-lymphoid pyroninophil cells appeared which is followed by an increased cell proliferation 24 hours after emetine injection. 48-60 hours after administration many macrophage-like cells appeared in the medullary sinuses. This macrophage invasion precedes the adherent cell accumulation in the subcapsular zone of the thymus suggesting a possible non-lymphoid (adherent) cell migration from the lymph node's paracortex to the thymus.
研究了强效免疫抑制剂吐根碱对胸腺和淋巴结的作用。胸腺的被膜下区细胞耗竭，大量黏附细胞积聚在该胸腺区域。髓质增大，但皮质与髓质的边界仍清晰可辨。在淋巴结的副皮质区（T细胞依赖区）出现了许多非淋巴细胞性嗜派洛宁细胞，吐根碱注射24小时后细胞增殖增加。给药48 - 60小时后，髓窦中出现许多巨噬细胞样细胞。这种巨噬细胞浸润先于胸腺被膜下区黏附细胞的积聚，提示可能存在从淋巴结副皮质区到胸腺的非淋巴细胞性（黏附）细胞迁移。
