Ma Ming, Liu Longsheng, Jin Wei, Chen Hong, Zhou Tao, Tong Busheng
Department of Otolaryngology, The First Affiliated Hospital of Anhui Medical University Hefei 238000, Anhui Province, China.
Department of Otolaryngology, Chaohu Hospital of Anhui Medical University Chaohu 238000, Anhui Province, China.
Am J Transl Res. 2021 Mar 15;13(3):1840-1846. eCollection 2021.
To explore the effects of desloratadine citrate disodium on the postoperative complications and inflammatory markers in patients with chronic sinusitis undergoing endoscopic sinus surgery.
From June 2019 to December 2020, the patients with chronic sinusitis who received treatment in our hospital were selected and divided into the control group (CG) and experimental group (EG). In both groups, patients were given endoscopic sinus surgery. On this basis, patients were treated with desloratadine citrate disodium in the EG. The total effective rate of the operation and the incidence of complications were compared between the two groups, and the VAS scores of clinical symptoms were compared between the two groups after treatment. Meanwhile, the changes of serum TIgE, ECP and inflammatory factors were compared between the two groups, and the nasal mucociliary clearing function was compared between the two groups before and after treatment.
After treatment, the total effective rate was 94.9% in the EG, which was significantly higher than that in the CG (82.2%). The levels of serum interleukin-6 (IL-6), interleukin-8 (IL-8), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) in the EG were significantly lower than those in the CG, and the levels of serum TIgE and ECP were also significantly lower than those in the CG. After treatment for 3 months, the mucociliary clearance rate and mucociliary clearance rate in the EG were significantly higher than those in the CG, while the saccharin clearance time was significantly shorter than that in the CG. The incidence of complications in the EG was significantly lower than that in the CG (all P < 0.05).
Desloratadine citrate disodium combined with endoscopic sinus surgery can improve the clinical efficacy, reduce the level of inflammatory factors and effectively reduce the incidence of complications in patients with chronic sinusitis.
探讨枸橼酸地氯雷他定二钠对慢性鼻窦炎患者行鼻内镜鼻窦手术后并发症及炎症标志物的影响。
选取2019年6月至2020年12月在我院接受治疗的慢性鼻窦炎患者，分为对照组（CG）和试验组（EG）。两组患者均接受鼻内镜鼻窦手术。在此基础上，试验组患者给予枸橼酸地氯雷他定二钠治疗。比较两组手术的总有效率及并发症发生率，比较两组治疗后临床症状的视觉模拟评分（VAS）。同时，比较两组血清总免疫球蛋白E（TIgE）、嗜酸性粒细胞阳离子蛋白（ECP）及炎症因子的变化，比较两组治疗前后鼻黏膜纤毛清除功能。
治疗后，试验组总有效率为94.9%，显著高于对照组（82.2%）。试验组血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、高敏C反应蛋白（hs-CRP）及肿瘤坏死因子-α（TNF-α）水平显著低于对照组，血清TIgE和ECP水平也显著低于对照组。治疗3个月后，试验组的黏液纤毛清除率和黏液纤毛转运率显著高于对照组，而糖精清除时间显著短于对照组。试验组并发症发生率显著低于对照组（均P<0.05）。
枸橼酸地氯雷他定二钠联合鼻内镜鼻窦手术可提高慢性鼻窦炎患者的临床疗效，降低炎症因子水平，有效降低并发症发生率。
