Zhang Lei, Zhao Yao, Lu Yan, He Pingping, Zhang Peng, Lv Zhanhui, Shen Yixin
Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Department of Orthopaedics, Binzhou Central Hospital Affiliated to Binzhou Medical University, Binzhou, Shandong 251700, P.R. China.
Exp Ther Med. 2020 Sep;20(3):2305-2310. doi: 10.3892/etm.2020.8941. Epub 2020 Jun 25.
The present study investigated the effects of vacuum sealing drainage (VSD) to improve the therapeutic efficacy in patients with orthopedic trauma (OT) and reduce post-operative infection and lower-limb deep venous thrombosis (DVT) through a retrospective analysis. A total of 76 patients with OT treated at our hospital were selected for observation. The patients were divided into the control group (CG; n=37) and the experimental group (EG; n=39) according to the treatment administered. For patients in the CG, routine dressing changes were applied. Patients in the EG underwent VSD treatment. The dressing change frequency, time between the first and second operation, hospital stay, treatment efficacy, wound healing time, interleukin-6 (IL-6) serum level, tumor necrosis factor-α (TNF-α) serum level, incidence of post-operative infection and incidence of lower-limb DVT were compared between the two groups. The dressing change frequency in the EG was less than that in the CG. The time between the first and second operation and hospital stay were shorter in the EG than in the CG (P<0.05). The total effective rate in the EG was 97.44%, which was higher than that in the CG (78.38%; P<0.05). The wound healing time in the EG was 1.72±0.73 weeks and shorter than that in the CG (2.23±0.85 weeks; P<0.05). With the progression of treatment, the serum IL-6 and TNF-α levels decreased in the two groups, but the levels in the EG were lower than those in the CG (P<0.05). The incidence of post-operative infection and lower-limb venous thrombosis in the EG were 7.69 and 0.00%, respectively, and lower than those in the CG (27.03 and 13.01%, respectively; P<0.05). In the treatment of OT, VSD may reduce the dressing change frequency, shorten the operation time and hospital stay, accelerate wound healing and reduce post-operative infection and lower-limb DVT. Thus, the VSD treatment method is worthy of promotion and implementation in clinic.
本研究通过回顾性分析，探讨了负压封闭引流（VSD）对提高骨科创伤（OT）患者治疗效果、降低术后感染及下肢深静脉血栓形成（DVT）的影响。选取我院收治的76例OT患者进行观察。根据治疗方式将患者分为对照组（CG；n = 37）和实验组（EG；n = 39）。CG组患者采用常规换药。EG组患者接受VSD治疗。比较两组患者的换药频率、首次与第二次手术间隔时间、住院时间、治疗效果、伤口愈合时间、血清白细胞介素-6（IL-6）水平、血清肿瘤坏死因子-α（TNF-α）水平、术后感染发生率及下肢DVT发生率。EG组的换药频率低于CG组。EG组的首次与第二次手术间隔时间及住院时间均短于CG组（P<0.05）。EG组的总有效率为97.44%，高于CG组（78.38%；P<0.05）。EG组的伤口愈合时间为1.72±0.73周，短于CG组（2.23±0.85周；P<0.05）。随着治疗进展，两组患者的血清IL-6和TNF-α水平均下降，但EG组低于CG组（P<0.05）。EG组的术后感染发生率和下肢静脉血栓形成发生率分别为7.69%和0.00%，低于CG组（分别为27.03%和13.01%；P<0.05）。在OT治疗中，VSD可减少换药频率，缩短手术时间和住院时间，加速伤口愈合，降低术后感染及下肢DVT。因此，VSD治疗方法值得在临床推广应用。
