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大麻生物活性肽通过Akt/GSK3β/β-连环蛋白信号通路对Hep3B肝癌细胞的抗癌特性

Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β-catenin signaling pathway.

作者信息

Wei Lian-Hui, Dong Yan, Sun Yu-Feng, Mei Xue-Song, Ma Xue-Song, Shi Jie, Yang Qing-Li, Ji Yan-Ru, Zhang Zheng-Hai, Sun Hu-Nan, Sun Xing-Rong, Song Shu-Min

机构信息

Daqing Branch of the Heilongjiang Academy of Sciences Daqing China.

College of Life Science and Technology Heilongjiang Bayi Agricultural University Daqing China.

出版信息

Food Sci Nutr. 2021 Feb 9;9(4):1833-1841. doi: 10.1002/fsn3.1976. eCollection 2021 Apr.

DOI:10.1002/fsn3.1976
PMID:33841802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8020916/
Abstract

Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small molecular weight HP from hemp seed and investigate its anticancer properties in Hep3B human liver cancer cells. We demonstrate that HP treatment increased apoptosis, reduced cell viability, and reduced cell migration in Hep3B human liver cancer cells without affecting the normal liver cell line L02. We correlate these phenotypes with increased cellular ROS levels, upregulation of cleaved caspase 3 and Bad, and downregulation of antiapoptotic Bcl-2. HP treatment led to increased Akt and GSK-3β phosphorylation, with subsequent downregulation of β-catenin, suggesting β-catenin signaling modulation as a critical mechanism by which HP exhibits anticancer properties. Our findings suggest HP are of potential therapeutic interest for liver cancer treatment.

摘要

食源性蛋白质水解产物具有生物活性，在许多人类疾病环境中可能具有治疗作用。通过对大麻蛋白进行可控水解产生的大麻肽（HP）具有多种健康益处，具有药用价值。在本研究中，我们从大麻籽中制备了小分子量的HP，并研究了其在Hep3B人肝癌细胞中的抗癌特性。我们证明，HP处理可增加Hep3B人肝癌细胞的凋亡，降低细胞活力，并减少细胞迁移，而不影响正常肝细胞系L02。我们将这些表型与细胞内ROS水平升高、裂解的caspase 3和Bad上调以及抗凋亡Bcl-2下调相关联。HP处理导致Akt和GSK-3β磷酸化增加，随后β-连环蛋白下调，表明β-连环蛋白信号调节是HP发挥抗癌特性的关键机制。我们的研究结果表明，HP对肝癌治疗具有潜在的治疗意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/de9a81a484d3/FSN3-9-1833-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/4a365984aa26/FSN3-9-1833-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/74cec31a8650/FSN3-9-1833-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/adf457d48447/FSN3-9-1833-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/de9a81a484d3/FSN3-9-1833-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/4a365984aa26/FSN3-9-1833-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/74cec31a8650/FSN3-9-1833-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/adf457d48447/FSN3-9-1833-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/8020916/de9a81a484d3/FSN3-9-1833-g001.jpg

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