Department of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey.
Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Molecules. 2018 Dec 10;23(12):3266. doi: 10.3390/molecules23123266.
Due to renewed interest in the cultivation and production of Italian L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, α-amylase, α-glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (, , , and spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.
由于对意大利薰衣草的种植和生产重新产生了兴趣，我们提出了一种多方法学方法来探索这种植物的精油和芳香水的化学和生物学特性。我们报告了化学组成，包括大麻素含量、挥发性成分、酚类和类黄酮模式以及颜色特征。然后，我们证明了在意大利种植的这种植物作为抗氧化化合物的来源在对抗一大类酶（胰脂肪酶、α-淀粉酶、α-葡萄糖苷酶和胆碱酯酶）和选择临床上相关的、多药敏感的和多药耐药的微生物菌株（ 、 、 和 spp.）方面的民族药理学相关性，评估了对正常和恶性细胞系的细胞毒性作用。还对 幼虫进行了初步的体内细胞毒性实验。结果证实了这种天然产物作为具有重要生物活性分子的丰富来源的用途，特别强调了柚皮素的作用，柚皮素是最重要的次生代谢物之一。
