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Commentary on Ferguson, et al., "Impact of Non-pharmaceutical Interventions (NPIs) to Reduce COVID-19 Mortality and Healthcare Demand".评 Ferguson 等人的“减少 COVID-19 死亡率和医疗需求的非药物干预（NPIs）的影响”一文。
Bull Math Biol. 2020 Apr 8;82(4):52. doi: 10.1007/s11538-020-00726-x.
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Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19.神经感染可能对新冠病毒疾病的病理生理学和临床表现产生影响。
Acta Physiol (Oxf). 2020 Jul;229(3):e13473. doi: 10.1111/apha.13473. Epub 2020 Apr 11.
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The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients.SARS-CoV2 的神经侵袭性可能在 COVID-19 患者的呼吸衰竭中起作用。
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学：对病毒起源和受体结合的影响。
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.2019 年中国肺炎患者中的一种新型冠状病毒。
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Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?人类冠状病毒和其他呼吸道病毒：被低估的中枢神经系统机会性病原体？
Viruses. 2019 Dec 20;12(1):14. doi: 10.3390/v12010014.
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Histology of Brain Trauma and Hypoxia-Ischemia.脑外伤与缺氧缺血的组织学
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Neurologic Alterations Due to Respiratory Virus Infections.呼吸道病毒感染所致的神经功能改变
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10
Coronavirus Infections in the Central Nervous System and Respiratory Tract Show Distinct Features in Hospitalized Children.住院儿童中枢神经系统和呼吸道的冠状病毒感染呈现出不同特征。
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新型冠状病毒肺炎的潜在神经表现

Potential Neurologic Manifestations of COVID-19.

作者信息

Nordvig Anna S, Fong Kathryn T, Willey Joshua Z, Thakur Kiran T, Boehme Amelia K, Vargas Wendy S, Smith Craig J, Elkind Mitchell S V

机构信息

Department of Neurology (ASN, KTF, JZW, KTT, AKB, WSV, MSVE), Vagelos College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (AKB, MSVE), Mailman School of Public Health, Columbia University, New York, NY; Division of Cardiovascular Sciences (CJS), Lydia Becker Institute of Immunology and Inflammation, University of Manchester; and Manchester Centre for Clinical Neurosciences (CJS), Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom.

出版信息

Neurol Clin Pract. 2021 Apr;11(2):e135-e146. doi: 10.1212/CPJ.0000000000000897.

DOI:10.1212/CPJ.0000000000000897
PMID:33842082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8032406/
Abstract

PURPOSE OF REVIEW

Neurologic complications are increasingly recognized in the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This coronavirus is related to severe acute respiratory syndrome coronavirus (SARS-CoV) and other human coronavirus-related illnesses that are associated with neurologic symptoms. These symptoms raise the question of a neuroinvasive potential of SARS-CoV-2.

RECENT FINDINGS

Potential neurologic symptoms and syndromes of SARS-CoV-2 include headache, fatigue, dizziness, anosmia, ageusia, anorexia, myalgias, meningoencephalitis, hemorrhage, altered consciousness, Guillain-Barré syndrome, syncope, seizure, and stroke. In addition, we discuss neurologic effects of other coronaviruses, special considerations for management of neurologic patients, and possible long-term neurologic and public health sequelae.

SUMMARY

As SARS-CoV-2 is projected to infect a large part of the world's population, understanding the potential neurologic implications of COVID-19 will help neurologists and others recognize and intervene in neurologic morbidity during and after the pandemic of 2020.

摘要

综述目的

在2019冠状病毒病（COVID-19）大流行中，神经系统并发症越来越受到关注。COVID-19由新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起。这种冠状病毒与严重急性呼吸综合征冠状病毒（SARS-CoV）以及其他与神经系统症状相关的人类冠状病毒疾病有关。这些症状引发了SARS-CoV-2是否具有神经侵袭潜力的问题。

最新发现

SARS-CoV-2潜在的神经系统症状和综合征包括头痛、疲劳、头晕、嗅觉丧失、味觉丧失、厌食、肌痛、脑膜脑炎、出血、意识改变、吉兰-巴雷综合征、晕厥、癫痫发作和中风。此外，我们还讨论了其他冠状病毒的神经学影响、神经系统疾病患者管理的特殊注意事项以及可能的长期神经学和公共卫生后遗症。

总结

由于预计SARS-CoV-2将感染世界上很大一部分人口，了解COVID-19潜在的神经学影响将有助于神经科医生和其他人员在2020年大流行期间及之后识别并干预神经系统疾病。