Nordvig Anna S, Fong Kathryn T, Willey Joshua Z, Thakur Kiran T, Boehme Amelia K, Vargas Wendy S, Smith Craig J, Elkind Mitchell S V
Department of Neurology (ASN, KTF, JZW, KTT, AKB, WSV, MSVE), Vagelos College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (AKB, MSVE), Mailman School of Public Health, Columbia University, New York, NY; Division of Cardiovascular Sciences (CJS), Lydia Becker Institute of Immunology and Inflammation, University of Manchester; and Manchester Centre for Clinical Neurosciences (CJS), Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom.
Neurol Clin Pract. 2021 Apr;11(2):e135-e146. doi: 10.1212/CPJ.0000000000000897.
Neurologic complications are increasingly recognized in the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This coronavirus is related to severe acute respiratory syndrome coronavirus (SARS-CoV) and other human coronavirus-related illnesses that are associated with neurologic symptoms. These symptoms raise the question of a neuroinvasive potential of SARS-CoV-2.
Potential neurologic symptoms and syndromes of SARS-CoV-2 include headache, fatigue, dizziness, anosmia, ageusia, anorexia, myalgias, meningoencephalitis, hemorrhage, altered consciousness, Guillain-Barré syndrome, syncope, seizure, and stroke. In addition, we discuss neurologic effects of other coronaviruses, special considerations for management of neurologic patients, and possible long-term neurologic and public health sequelae.
As SARS-CoV-2 is projected to infect a large part of the world's population, understanding the potential neurologic implications of COVID-19 will help neurologists and others recognize and intervene in neurologic morbidity during and after the pandemic of 2020.
在2019冠状病毒病（COVID-19）大流行中，神经系统并发症越来越受到关注。COVID-19由新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起。这种冠状病毒与严重急性呼吸综合征冠状病毒（SARS-CoV）以及其他与神经系统症状相关的人类冠状病毒疾病有关。这些症状引发了SARS-CoV-2是否具有神经侵袭潜力的问题。
SARS-CoV-2潜在的神经系统症状和综合征包括头痛、疲劳、头晕、嗅觉丧失、味觉丧失、厌食、肌痛、脑膜脑炎、出血、意识改变、吉兰-巴雷综合征、晕厥、癫痫发作和中风。此外，我们还讨论了其他冠状病毒的神经学影响、神经系统疾病患者管理的特殊注意事项以及可能的长期神经学和公共卫生后遗症。
由于预计SARS-CoV-2将感染世界上很大一部分人口，了解COVID-19潜在的神经学影响将有助于神经科医生和其他人员在2020年大流行期间及之后识别并干预神经系统疾病。
