CD276在癌症中的作用。
The Role of CD276 in Cancers.
作者信息
Liu Shengzhuo, Liang Jiayu, Liu Zhihong, Zhang Chi, Wang Yang, Watson Alice Helen, Zhou Chuan, Zhang Fan, Wu Kan, Zhang Fuxun, Lu Yiping, Wang Xianding
机构信息
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
出版信息
Front Oncol. 2021 Mar 26;11:654684. doi: 10.3389/fonc.2021.654684. eCollection 2021.
OBJECTIVE
Aberrant expression of the immune checkpoint molecule, CD276, also known as B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe the role of CD276 in malignancies and its potential therapeutic effect.
DATA SOURCES
Database including PubMed, EMbase, Cochrane Library, CNKI, and Clinical Trails.gov were searched for eligible studies and reviews. Study selection: Original studies and review articles on the topic of CD276 in tumors were retrieved.
RESULTS
CD276 is an immune checkpoint molecule in the epithelial mesenchymal transition (EMT) pathway. In this review, we evaluated the available evidence on the expression and regulation of CD276. We also assessed the role of CD276 within the immune micro-environment, effect on tumor progression, and the potential therapeutic effect of CD276 targeted therapy for malignancies.
CONCLUSION
CD276 plays an essential role in cell proliferation, invasion, and migration in malignancies. Results from most recent studies indicate CD276 could be a promising therapeutic target for malignant tumors.
目的
免疫检查点分子CD276（也称为B7-H3）的异常表达与肿瘤发生相关。在本综述中，我们旨在全面描述CD276在恶性肿瘤中的作用及其潜在的治疗效果。
数据来源
检索包括PubMed、EMbase、Cochrane图书馆、中国知网和Clinical Trails.gov在内的数据库，以查找符合条件的研究和综述。研究选择：检索关于肿瘤中CD276主题的原始研究和综述文章。
结果
CD276是上皮-间质转化（EMT）途径中的一种免疫检查点分子。在本综述中，我们评估了关于CD276表达和调控的现有证据。我们还评估了CD276在免疫微环境中的作用、对肿瘤进展的影响以及CD276靶向治疗恶性肿瘤的潜在治疗效果。
结论
CD276在恶性肿瘤的细胞增殖、侵袭和迁移中起重要作用。最新研究结果表明，CD276可能是恶性肿瘤的一个有前景的治疗靶点。
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