Winz Cassandra, Suh Nanjoo
Department of Chemical Biology, Ernest Mario School of Pharmacy, Piscataway, NJ, USA.
Toxicology Graduate Program, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
J Cancer Prev. 2021 Mar 30;26(1):18-24. doi: 10.15430/JCP.2021.26.1.18.
Endocrine disruptors, such as bisphenol A (BPA), have become more frequently present in the environment as contaminants, especially in industrialized countries. Long-term effects of these environmental contaminants in humans are elusive. With their structural similarity to estrogen, many environmental contaminants including BPA, have been shown to mimic the biological functions of estrogen, potentially contributing to the development of breast cancer. It has been well established that BPA exerts estrogenic activity in animal models and in vitro systems. There is a concern for adverse effects from the exposure to BPA in regard to developmental and reproductive toxicities. However, the mechanisms by which BPA promotes breast cancer development remain unknown. Understanding the role of endocrine disruptors and their key mechanisms of action is important for public health, especially by providing a foundation for a better intervention approach in cancer prevention.
内分泌干扰物，如双酚A（BPA），作为污染物在环境中出现得越来越频繁，尤其是在工业化国家。这些环境污染物对人类的长期影响尚不清楚。由于许多环境污染物（包括BPA）在结构上与雌激素相似，已被证明可模拟雌激素的生物学功能，这可能会促使乳腺癌的发生。众所周知，BPA在动物模型和体外系统中具有雌激素活性。人们担心接触BPA会对发育和生殖毒性产生不良影响。然而，BPA促进乳腺癌发展的机制仍然未知。了解内分泌干扰物的作用及其关键作用机制对公共卫生很重要，特别是为更好的癌症预防干预方法提供基础。
