血清成纤维细胞生长因子 19 水平与中国人的冠状动脉疾病呈负相关。
Serum levels of fibroblast growth factor 19 are inversely associated with coronary artery disease in chinese individuals.
机构信息
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
出版信息
PLoS One. 2013 Aug 7;8(8):e72345. doi: 10.1371/journal.pone.0072345. Print 2013.
BACKGROUND
The fibroblast growth factor 19 (FGF19) has been implicated in recent studies as a potential regulator of glucose and lipid metabolism, which may lead to atherosclerosis. Here, we investigated the association of FGF19 with the presence and severity of coronary artery disease (CAD) in a Chinese population.
METHODS
A total of 315 patients with suspected or established CAD, including 205 males and 110 postmenopausal females, were enrolled and assessed by coronary angiography. CAD severity was determined by the Gensini score. Serum FGF19 was measured by quantitative sandwich ELISA.
RESULTS
FGF19 levels were not significantly different between male and female patients (median [interquartile range], 143.40 [87.96-250.80] vs. 141.60 [87.13-226.32] pg/mL, P = 0.773). CAD patients had lower levels of FGF19 than those without CAD (128.20 [80.62-226.58] vs. 188.00 [105.10-284.70] pg/mL, P = 0.007). FGF19 was negatively correlated with 2hPG (r = -0.150, P = 0.008), FINS (r = -0.169, P = 0.004), HOMA-IR (r = -0.171, P = 0.004), and the Gensini score (r = -0.141, P = 0.012), but positively correlated with HDL-c (r = 0.116, P = 0.041) and adiponectin (r = 0.128, P = 0.024). Moreover, FGF19 was found to be independently correlated with 2hPG (β = -0.146, P = 0.022) and adiponectin (β = 0.154, P = 0.016). After adjusting for other CAD risk factors, FGF19 was demonstrated to be an independent factor for Gensini score (β = -0.140, P = 0.019) and the presence of CAD (β = -1.248, P = 0.036).
CONCLUSIONS
Serum FGF19 is associated with the presence and severity of CAD in a Chinese population.
背景
成纤维细胞生长因子 19（FGF19）在最近的研究中被认为是调节葡萄糖和脂质代谢的潜在因子，而这可能会导致动脉粥样硬化。在此，我们在中国人群中研究了 FGF19 与冠状动脉疾病（CAD）的存在和严重程度之间的关系。
方法
共纳入 315 例疑似或确诊 CAD 的患者，包括 205 名男性和 110 名绝经后女性，所有患者均接受冠状动脉造影评估。CAD 严重程度采用 Gensini 评分来确定。采用定量夹心 ELISA 法检测血清 FGF19 水平。
结果
男性和女性患者的 FGF19 水平无显著差异（中位数[四分位数间距]，143.40[87.96-250.80]vs.141.60[87.13-226.32]pg/mL，P=0.773）。与无 CAD 的患者相比，CAD 患者的 FGF19 水平较低（128.20[80.62-226.58]vs.188.00[105.10-284.70]pg/mL，P=0.007）。FGF19 与 2hPG（r=-0.150，P=0.008）、FINS（r=-0.169，P=0.004）、HOMA-IR（r=-0.171，P=0.004）和 Gensini 评分（r=-0.141，P=0.012）呈负相关，与 HDL-c（r=0.116，P=0.041）和脂联素（r=0.128，P=0.024）呈正相关。此外，FGF19 与 2hPG（β=-0.146，P=0.022）和脂联素（β=0.154，P=0.016）呈独立相关。在调整其他 CAD 危险因素后，FGF19 是 Gensini 评分（β=-0.140，P=0.019）和 CAD 存在的独立因素（β=-1.248，P=0.036）。
结论
在中国人群中，血清 FGF19 与 CAD 的存在和严重程度相关。
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