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Transferrin: Biology and Use in Receptor-Targeted Nanotherapy of Gliomas.

作者信息

Koneru Tejaswi, McCord Eva, Pawar Shreya, Tatiparti Katyayani, Sau Samaresh, Iyer Arun K

机构信息

Use-Inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, United States.

Walled Lake Central High School, Commerce Charter Township, Michigan 48390, United States.

出版信息

ACS Omega. 2021 Mar 22;6(13):8727-8733. doi: 10.1021/acsomega.0c05848. eCollection 2021 Apr 6.

DOI:10.1021/acsomega.0c05848
PMID:33842744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8028004/
Abstract

Gliomas constitute 80% of malignant brain tumors. The survival rate of patients diagnosed with malignant gliomas is only 34.4%, as seen in both adults as well as children. The biggest challenge in treatment of gliomas is the impenetrable blood-brain barrier. With the availability of only a very few choices of chemotherapeutics in the treatment of gliomas, it is imperative that a novel strategy to effectively deliver drugs into the brain is researched and applied. The most popular strategy that is gaining importance is the receptor-mediated uptake of targeted nanoparticles comprising of ligands specific to the receptors. This review discusses briefly one such receptor called the transferrin receptor that is highly expressed in the brain and can be applied effectively for targeted nanoparticle delivery systems in gliomas.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/b616d53f2b1d/ao0c05848_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/d006bb050331/ao0c05848_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/c5efbf63562c/ao0c05848_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/e690f271031f/ao0c05848_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/b616d53f2b1d/ao0c05848_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/d006bb050331/ao0c05848_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/c5efbf63562c/ao0c05848_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/e690f271031f/ao0c05848_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/8028004/b616d53f2b1d/ao0c05848_0004.jpg

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Transferrin: Biology and Use in Receptor-Targeted Nanotherapy of Gliomas.

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[6]
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[7]
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[8]
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[10]
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本文引用的文献

[1]
Transferrin-Conjugated Docetaxel-PLGA Nanoparticles for Tumor Targeting: Influence on MCF-7 Cell Cycle.

Polymers (Basel). 2019-11-19

[2]
Targeting the transferrin receptor for brain drug delivery.

Prog Neurobiol. 2019-7-31

[3]
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review.

J Adv Res. 2018-6-25

[4]
Transferrin receptor 1 in cancer: a new sight for cancer therapy.

Am J Cancer Res. 2018-6-1

[5]
Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles.

Theranostics. 2018-5-24

[6]
Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier.

PLoS One. 2018-6-11

[7]
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

Nat Commun. 2018-5-18

[8]
Transferrin-targeted, resveratrol-loaded liposomes for the treatment of glioblastoma.

J Control Release. 2018-3-6

[9]
Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.

Biochemistry. 2018-3-6

[10]
Targeting transferrin receptor delivery of temozolomide for a potential glioma stem cell-mediated therapy.

Oncotarget. 2017-8-10

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