Koneru Tejaswi, McCord Eva, Pawar Shreya, Tatiparti Katyayani, Sau Samaresh, Iyer Arun K
Use-Inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, United States.
Walled Lake Central High School, Commerce Charter Township, Michigan 48390, United States.
ACS Omega. 2021 Mar 22;6(13):8727-8733. doi: 10.1021/acsomega.0c05848. eCollection 2021 Apr 6.
Gliomas constitute 80% of malignant brain tumors. The survival rate of patients diagnosed with malignant gliomas is only 34.4%, as seen in both adults as well as children. The biggest challenge in treatment of gliomas is the impenetrable blood-brain barrier. With the availability of only a very few choices of chemotherapeutics in the treatment of gliomas, it is imperative that a novel strategy to effectively deliver drugs into the brain is researched and applied. The most popular strategy that is gaining importance is the receptor-mediated uptake of targeted nanoparticles comprising of ligands specific to the receptors. This review discusses briefly one such receptor called the transferrin receptor that is highly expressed in the brain and can be applied effectively for targeted nanoparticle delivery systems in gliomas.
胶质瘤占恶性脑肿瘤的80%。无论是成人还是儿童，被诊断为恶性胶质瘤的患者生存率仅为34.4%。治疗胶质瘤的最大挑战是难以穿透的血脑屏障。由于在胶质瘤治疗中化疗药物的选择非常有限，因此必须研究并应用一种将药物有效输送到大脑的新策略。越来越重要的最流行策略是受体介导的靶向纳米颗粒摄取，该纳米颗粒由受体特异性配体组成。本综述简要讨论了一种这样的受体，即转铁蛋白受体，它在大脑中高度表达，可有效应用于胶质瘤的靶向纳米颗粒递送系统。
