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本文引用的文献

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The emergence of innovative cannabis distribution projects in the downtown eastside of Vancouver, Canada.加拿大温哥华东区市中心创新性大麻分销项目的出现。
Int J Drug Policy. 2020 Apr 11;79:102737. doi: 10.1016/j.drugpo.2020.102737.
2
"Chasing the pain relief, not the high": Experiences managing pain after opioid reductions among patients with HIV and a history of substance use.“追求缓解疼痛,而非快感”:HIV 感染者和药物滥用史患者在减少阿片类药物后管理疼痛的体验。
PLoS One. 2020 Mar 25;15(3):e0230408. doi: 10.1371/journal.pone.0230408. eCollection 2020.
3
Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis.药物使用者中报告慢性疼痛的人与同时使用大麻和非法阿片类药物的频率:一项纵向分析。
PLoS Med. 2019 Nov 19;16(11):e1002967. doi: 10.1371/journal.pmed.1002967. eCollection 2019 Nov.
4
Cannabis legalization in Canada: What are the potential implications and barriers for people living with HIV?加拿大的大麻合法化:对艾滋病毒感染者有哪些潜在影响和障碍?
Int J Drug Policy. 2019 Dec;74:191-192. doi: 10.1016/j.drugpo.2019.09.022. Epub 2019 Oct 18.
5
Patterns in Outpatient Benzodiazepine Prescribing in the United States.美国门诊苯二氮䓬类药物处方模式。
JAMA Netw Open. 2019 Jan 4;2(1):e187399. doi: 10.1001/jamanetworkopen.2018.7399.
6
Exposure-Response Association Between Concurrent Opioid and Benzodiazepine Use and Risk of Opioid-Related Overdose in Medicare Part D Beneficiaries.在医疗保险处方药受益人群中,同时使用阿片类药物和苯二氮䓬类药物与阿片类药物相关过量风险之间的暴露-反应关联。
JAMA Netw Open. 2018 Jun 1;1(2):e180919. doi: 10.1001/jamanetworkopen.2018.0919.
7
Pain in people living with HIV and its association with healthcare resource use, well being and functional status.HIV 感染者的疼痛及其与医疗资源利用、健康状况和功能状态的关系。
AIDS. 2018 Nov 28;32(18):2697-2706. doi: 10.1097/QAD.0000000000002021.
8
Emerging Evidence for Cannabis' Role in Opioid Use Disorder.大麻在阿片类物质使用障碍中作用的新证据。
Cannabis Cannabinoid Res. 2018 Sep 1;3(1):179-189. doi: 10.1089/can.2018.0022. eCollection 2018.
9
Transitions in income generation among marginalized people who use drugs: A qualitative study on recycling and vulnerability to violence.边缘化吸毒人群的收入来源转变:关于回收利用和易受暴力侵害性的定性研究。
Int J Drug Policy. 2018 Sep;59:36-43. doi: 10.1016/j.drugpo.2018.06.014. Epub 2018 Jul 4.
10
Frequency of Cannabis Use and Medical Cannabis Use Among Persons Living With HIV in the United States: Findings From a Nationally Representative Sample.美国艾滋病毒感染者中使用大麻和医用大麻的频率:来自全国代表性样本的结果。
AIDS Educ Prev. 2018 Apr;30(2):169-181. doi: 10.1521/aeap.2018.30.2.169.

大麻在药物使用的 HIV 感染者疼痛管理中的作用:一项定性研究。

The role of cannabis in pain management among people living with HIV who use drugs: A qualitative study.

机构信息

British Columbia Centre on Substance Use, Vancouver, Canada.

Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

出版信息

Drug Alcohol Rev. 2021 Nov;40(7):1325-1333. doi: 10.1111/dar.13294. Epub 2021 Apr 11.

DOI:10.1111/dar.13294
PMID:33843074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8580359/
Abstract

INTRODUCTION

People living with HIV who use drugs commonly experience chronic pain and often use illicit opioids to manage pain. Recent research suggests people living with HIV use cannabis for pain relief, including as an adjunct to opioids. This underscores the need to better understand how people living with HIV who use drugs use cannabis for pain management, particularly as cannabis markets are undergoing changes due to cannabis legalisation.

METHODS

From September 2018 to April 2019, we conducted in-depth interviews with 25 people living with HIV who use drugs in Vancouver, Canada to examine experiences using cannabis to manage pain. Interviews were audio-recorded, transcribed and coded. Themes were identified using inductive and deductive approaches.

RESULTS

Most participants reported that using cannabis for pain management helped improve daily functioning. Some participants turned to cannabis as a supplement or periodic alternative to prescription and illicit drugs (e.g. benzodiazepines, opioids) used to manage pain and related symptoms. Nonetheless, participants' access to legal cannabis was limited and most continued to obtain cannabis from illicit sources, which provided access to cannabis that was free or deemed to be affordable.

DISCUSSION AND CONCLUSIONS

Cannabis use may lead to reduced use of prescription and illicit drugs for pain management among some people living with HIV who use drugs. Our findings add to growing calls for additional research on the role of cannabis in pain management and harm reduction, and suggest the need for concrete efforts to ensure equitable access to cannabis.

摘要

简介

患有艾滋病且吸毒的人群普遍会经历慢性疼痛,且经常会使用非法阿片类药物来缓解疼痛。最近的研究表明,艾滋病患者会使用大麻来缓解疼痛,包括作为阿片类药物的辅助药物。这突显了人们需要更好地了解艾滋病患者如何使用大麻来进行疼痛管理,尤其是由于大麻合法化,大麻市场正在发生变化。

方法

2018 年 9 月至 2019 年 4 月,我们在加拿大温哥华对 25 名患有艾滋病且吸毒的人进行了深入访谈,以研究他们使用大麻缓解疼痛的经验。访谈进行了录音、转写和编码。采用归纳和演绎方法确定主题。

结果

大多数参与者报告称,使用大麻缓解疼痛有助于改善日常功能。一些参与者转向大麻作为补充或周期性替代处方和非法药物(如苯二氮䓬类、阿片类药物)来管理疼痛和相关症状。然而,参与者获得合法大麻的机会有限,大多数人继续从非法来源获取大麻,这些来源提供了免费或被认为负担得起的大麻。

讨论和结论

大麻的使用可能会导致一些患有艾滋病且吸毒的人群减少使用处方和非法药物来管理疼痛。我们的研究结果增加了对大麻在疼痛管理和减少伤害方面的作用的进一步研究的呼吁,并表明需要做出具体努力确保公平获得大麻。