Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Department of Anatomy and Medical Imaging & Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Brain Inj. 2021 May 12;35(6):621-644. doi: 10.1080/02699052.2021.1895313. Epub 2021 Apr 11.
Traumatic brain injury (TBI) is a major public health problem. The majority of TBIs are in the form of mild TBI (also known as concussion) with sports-related concussion (SRC) receiving public attention in recent years.Here we have performed a systematic review of the literature on the use of Diffusion Tensor Imaging (DTI) on sports-related concussion and subconcussive injuries. Our review found different patterns of change in DTI parameters between concussed and subconcussed groups. The Fractional Anisotropy (FA) was either unchanged or increased for the concussion group, while the subconcussed group generally experienced a decrease in FA. A reverse pattern was observed for Mean Diffusivity (MD) - where the concussed group experienced a decrease in MD while the subconcussed group showed an increase in MD. However, in general, discrepancies were observed in the results reported in the literature - likely due to the huge variations in DTI acquisition parameters, and image processing and analysis methods used in these studies. This calls for more comprehensive and well-controlled studies in this field, including those that combine the advanced brain imaging with biomechancial modeling and kinematic sensors - to shed light on the underlying mechanisms behind the structural changes observed from the imaging studies.
创伤性脑损伤（TBI）是一个主要的公共卫生问题。大多数 TBI 为轻度 TBI（也称为脑震荡），近年来，与运动相关的脑震荡（SRC）引起了公众的关注。在这里，我们对与运动相关的脑震荡和亚临床损伤的弥散张量成像（DTI）应用进行了系统评价。我们的综述发现，在脑震荡组和亚临床组之间，DTI 参数的变化模式不同。FA 在脑震荡组中不变或增加，而亚临床组通常表现出 FA 的降低。MD 则观察到相反的模式——脑震荡组 MD 降低，而亚临床组 MD 增加。然而，文献中报告的结果存在差异——可能是由于这些研究中 DTI 采集参数、图像处理和分析方法的巨大差异所致。这就需要在该领域开展更全面和严格控制的研究，包括将先进的脑成像与生物力学建模和运动传感器相结合的研究，以揭示影像学研究中观察到的结构变化背后的潜在机制。
