Division of Maternal Fetal Medicine, Ospedale Cristo Re Roma, Università di Roma Tor Vergata, Roma, Italy.
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, Federico II University of Naples, Naples, Italy.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):6302-6305. doi: 10.1080/14767058.2021.1910672. Epub 2021 Apr 11.
The use of Coronavirus 2 (SARS-CoV-2) vaccine in pregnant women is controversial and still not performed in Italy. Our objective was to evaluate the propensity of a population of Italian women to receive the vaccine and its psychological impact.
A prospective, observational study was performed on pregnant women attending Ospedale Cristo Re Università Roma TorVergata. A multi-section questionnaire was sent to each included woman on the first day of available SARS-CoV-2 vaccination. Part-A was finalized to acquire maternal characteristics and to test the women's perception of vaccinations in pregnancy and their fear-induced by vaccines. Part-B included the State-Trait-Anxiety-Inventory (STAI) a validated test for scoring trait anxiety (basal anxiety, STAI-T) and state anxiety (STAI-S). An abnormal value of STAI was considered when ≥40. Comparisons of maternal variables were performed according to their vaccine attitude.
The questionnaire was completed by 161 women (80.5% of the population considered). A positive attitude toward the vaccine was present in 136 (84.5%) women (positive) while the remaining 25.5% considered the vaccine not useful (negative). Among the former group 52.9% were favorable to obtain the vaccine during pregnancy despite the current national limitations, a percentage significantly higher ( = .02) than in the negative groups. Women with a negative attitude to the vaccine had a lower educational ( = .002) and employment level ( = .016) when compared to the positive group. In all the women a significant increase of STAI-S from STAI-T values was evidenced ( < .0001). The incidence of abnormal STAI T values (basal anxiety) was similar between the 2 groups ( = .81), while there was a significant increase of STAI-S values in the negative group (negative 88.0%; vs positive 63.4%; = .018).
The majority of pregnant women considered have a positive attitude to SARS-CoV-2 vaccine. Vaccine campaign seems to increase the maternal level of anxiety and this increase is more marked with a negative attitude toward the vaccine.
在意大利，使用冠状病毒 2（SARS-CoV-2）疫苗在孕妇中存在争议，尚未使用。我们的目的是评估意大利妇女群体接种疫苗的倾向及其心理影响。
对罗马 Tor Vergata 基督复临大学 Ospedale Cristo Re 的孕妇进行前瞻性、观察性研究。在 SARS-CoV-2 疫苗接种可用的第一天，向每位纳入的女性发送多部分问卷。第 A 部分旨在获取产妇特征，并测试女性对妊娠期间疫苗接种的看法及其对疫苗的恐惧。第 B 部分包括状态-特质焦虑量表（STAI），这是一种用于评分特质焦虑（基础焦虑，STAI-T）和状态焦虑（STAI-S）的经过验证的测试。当 STAI 值≥40 时，认为 STAI 值异常。根据疫苗态度比较了产妇变量。
共有 161 名女性（考虑的人群的 80.5%）完成了问卷。136 名（84.5%）女性对疫苗持积极态度（阳性），而其余 25.5%认为疫苗没有用（阴性）。在前一组中，52.9%的人赞成在目前国家限制下在怀孕期间接种疫苗，这一比例明显高于阴性组（ = .02）。对疫苗持消极态度的女性的教育程度（ = .002）和就业水平（ = .016）均低于阳性组。在所有女性中，从 STAI-T 值到 STAI-S 值的显著增加得到了证明（ < .0001）。两组之间异常 STAI T 值（基础焦虑）的发生率相似（ = .81），而阴性组的 STAI-S 值显著增加（阴性 88.0%；阳性 63.4%； = .018）。
大多数孕妇对 SARS-CoV-2 疫苗持积极态度。疫苗接种运动似乎会增加产妇的焦虑水平，而对疫苗的消极态度会使这种增加更加明显。
