雷尼替丁与氧自由基清除剂在失血性休克所致胃损伤中的作用
Ranitidine and oxygen derived free radical scavengers in haemorrhagic shock induced gastric lesions.
作者信息
Tsimoyiannis E C, Sarros C J, Tsimoyiannis J C, Moutesidou K, Akalestos G, Kotoulas O B
机构信息
Department of Surgery, G Hatzikosta General Hospital of Ioannina, Greece.
出版信息
Gut. 1988 Jun;29(6):826-9. doi: 10.1136/gut.29.6.826.
The role of oxygen derived free radicals in gastric lesions induced by haemorrhagic shock and the protective effect of oxygen radical scavengers, allopurinol and ranitidine, were investigated. Forty five rabbits underwent haemorrhagic shock for 30 minutes and reinfusion of shed blood. They were killed 30 minutes later. The animals were divided in five groups: A (n = 10): Control, B (n = 10): intravenous ranitidine pretreatment, C (n = 10): oral allopurinol, 24 and 2 h before surgery; D (n = 10): intravenous pretreatment with superoxide Dismutase plus catalase, E (n = 5): 60 minute haemorrhagic shock without reinfusion and treatment. Erosions and/or petechiae in all animals in Group A were observed. Three animals in group B and C and 2 in group D (p less than 0.005, p less than 0.001) had gastric lesions. The lesions in the pretreatment groups were significantly smaller than in controls. Oxygen radicals plus HCl play an important role in shock induced gastric lesions. Oxygen radical antagonists show a significant protective role.
研究了氧衍生自由基在失血性休克所致胃损伤中的作用以及氧自由基清除剂别嘌呤醇和雷尼替丁的保护作用。45只兔子经历30分钟的失血性休克并回输 shed blood。30分钟后将它们处死。动物被分为五组：A组（n = 10）：对照组；B组（n = 10）：静脉注射雷尼替丁预处理；C组（n = 10）：手术前24小时和2小时口服别嘌呤醇；D组（n = 10）：静脉注射超氧化物歧化酶加过氧化氢酶预处理；E组（n = 5）：60分钟失血性休克，不进行回输和治疗。观察到A组所有动物均有糜烂和/或瘀点。B组和C组各有3只动物，D组有2只动物（p < 0.005，p < 0.001）出现胃损伤。预处理组的损伤明显小于对照组。氧自由基加盐酸在休克诱导的胃损伤中起重要作用。氧自由基拮抗剂显示出显著的保护作用。 （注：原文中“shed blood”表述不太准确，可能是“失血”之类更合适的词，但按要求未作修改）
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