Department of Surgery, Medicine Dentistry and Morphological Sciences with Interest in Transplantation, Oncology and Regenerative Medicine, Institute of Pathology, University of Modena and Reggio Emilia, Polyclinic Hospital, Largo del Pozzo 71, 41124, Modena (MO), Italy.
Department of Life Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy.
J Thromb Thrombolysis. 2021 Nov;52(4):1043-1046. doi: 10.1007/s11239-021-02444-0. Epub 2021 Apr 12.
Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required.
METHODS/RESULTS: By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson's syndrome (catastrophic antiphospholipid syndrome).
A parallelism between this severe form of COVID-19 and Asherson's syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed.
2019 年冠状病毒病（COVID-19）是一种具有许多临床病理特征的复杂疾病，包括异常免疫血栓形成，迫切需要全面了解其发病机制。
方法/结果：通过多学科方法，我们在此报告了一名 44 岁菲律宾男性患者的灾难性 COVID-19 病例，该患者在死亡前不久被发现狼疮抗凝剂（LAC）阳性，发生在住院后 8 天，在标准高敏治疗无效的临床情况下，出现了 Asherson 综合征（灾难性抗磷脂综合征）。
可以得出这种严重形式的 COVID-19 与 Asherson 综合征之间存在平行关系。这两种疾病实际上都表现出细胞因子过度激活、血栓性微血管病、弥散性血管内凝血和多器官衰竭，它们与病毒感染有关，且死亡率很高。可能存在发生这两种重叠病症的遗传易感性。
