Applied and Environmental Physiology Unit, Department of Physiology, Bowen University, P.M.B 284, Iwo, Osun State, Nigeria.
Cardiovascular Physiology Unit, Department of Physiology, Bowen University, P.M.B 284, Iwo, Osun State, Nigeria.
Biol Trace Elem Res. 2022 Mar;200(3):1181-1189. doi: 10.1007/s12011-021-02711-4. Epub 2021 Apr 12.
Cardiovascular diseases have been associated with cadmium (Cd) and lead (Pb). Impaired Ca and Na/K-ATPase activities have also been linked to hemolytic and cardiovascular disorders. This study investigated the effect of rutin on Cd and/or Pb-induced cardiac and erythrocyte disorders in male rats. Twenty-five (25) male Wistar rats were treated as (n=5): Control, Pb (60 mg/kg, p.o), Cd (5 mg/kg, p.o), Pb + Cd, Rutin + Pb + Cd (50 mg/kg Rt, 60 mg/kg Pb, 5 mg/kg Cd, p.o). Plasma electrolyte and Ca- and Na/K-ATPase activities in the erythrocyte and heart of the rats were assayed. There was an increased and decreased activity of cardiac and erythrocyte Na/K-ATPase in Pb- (172%) and Cd- (33.7%) treated groups, respectively. However, rutin increased erythrocyte Na/K-ATPase activity in Cd + Pb when compared with Cd and Cd + Pb groups. Erythrocyte Ca-ATPase activity was decreased in the Pb (68%), Cd (68%) and Cd + Pb (55.3%) groups. Cardiac Na/K-ATPase activity was not altered in Pb and Cd groups while it decreased in Cd + Pb. Rutin increased the activity of the pump in Cd +Pb-treated rats compared to the Cd+Pb group. Therefore, rutin reversed cadmium- and lead-induced impaired cardiac and erythrocyte membrane Ca- and Na/K-ATPase activities. Graphical Abstract Dotted lines-decrease activity, curved lines-increased activity (created with BioRender.com ).
心血管疾病与镉 (Cd) 和铅 (Pb) 有关。钙 (Ca) 和钠/钾-ATP 酶活性的受损也与溶血性和心血管疾病有关。本研究探讨了芦丁对雄性大鼠镉和/或铅诱导的心脏和红细胞紊乱的影响。25 只雄性 Wistar 大鼠(n=5)分为以下几组：对照组、Pb(60mg/kg，口服)、Cd(5mg/kg，口服)、Pb+Cd、芦丁+Pb+Cd(50mg/kg Rt，60mg/kg Pb，5mg/kg Cd，口服)。测定大鼠血浆电解质和红细胞及心脏中的 Ca-和 Na/K-ATP 酶活性。Pb 处理组(172%)和 Cd 处理组(33.7%)的心脏和红细胞 Na/K-ATP 酶活性分别升高和降低。然而，与 Cd 和 Cd+Pb 组相比，芦丁增加了 Cd+Pb 组的红细胞 Na/K-ATP 酶活性。Pb(68%)、Cd(68%)和 Cd+Pb(55.3%)组的红细胞 Ca-ATP 酶活性降低。Pb 和 Cd 组的心脏 Na/K-ATP 酶活性没有改变，而 Cd+Pb 组则降低。与 Cd+Pb 组相比，芦丁增加了 Cd+Pb 处理大鼠泵的活性。因此，芦丁逆转了镉和铅诱导的心脏和红细胞膜 Ca-和 Na/K-ATP 酶活性受损。
