The AKT1 proto-oncogene maps to human chromosome 14, band q32.
作者信息
Staal S P, Huebner K, Croce C M, Parsa N Z, Testa J R
机构信息
Johns Hopkins Oncology Center, John Hopkins University School of Medicine, Baltimore, Maryland 21205.
出版信息
Genomics. 1988 Jan;2(1):96-8. doi: 10.1016/0888-7543(88)90114-0.
PMID:3384441
Abstract
The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.
摘要
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