Mierson S, Welter M E, Gennings C, DeSimone J A
Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Hypertension. 1988 Jun;11(6 Pt 1):519-22. doi: 10.1161/01.hyp.11.6.519.
Alterations in ion transport associated with hypertension have been found in a variety of organs. We used a modified Ussing chamber to compare the NaCl dependence of the short-circuit current across the dorsal lingual epithelium in vitro from spontaneously hypertensive rats (SHR) with that from Wistar-Kyoto rats (WKY). The short-circuit current in response to mucosal NaCl was less in SHR than in WKY at hyperosmotic concentrations (above 0.15 M and up to 2.0 M). Since ion transport in the lingual epithelium has been found to play a role in early events of salt taste transduction, the attenuation in the short-circuit current in hypertensive animals may be a factor in the enhanced salt preference of SHR compared with WKY.
在多种器官中均发现了与高血压相关的离子转运改变。我们使用改良的尤斯灌流小室，比较了自发性高血压大鼠（SHR）与Wistar-Kyoto大鼠（WKY）离体舌背上皮跨上皮短路电流对NaCl的依赖性。在高渗浓度（高于0.15M直至2.0M）下，SHR对黏膜NaCl产生的短路电流低于WKY。由于已发现舌上皮中的离子转运在盐味转导的早期事件中起作用，因此高血压动物短路电流的减弱可能是SHR相比于WKY盐偏好增强的一个因素。
