Jorquera L Aline, Ugarte C Daniela, Avilés L Carmen, Delpiano M Luis
Hospital Clínico San Borja Arriarán, Santiago, Chile.
Rev Chilena Infectol. 2020 Dec;37(6):769-774. doi: 10.4067/S0716-10182020000600769.
We report the case of an older infant with no prior morbidity that approximately 3 weeks after receiving MMR vaccination (measles, mumps, rubella) was hospitalized for feverish symptoms, increased parotid volume and compromised consciousness. Aseptic meningitis was diagnosed, detecting pleocytosis in the CSF, predominantly mononuclear, and confirming by molecular biology, presence of parotid virus in CSF. A study was carried out by the Institute of Public Health of Chile, where serology (IgM and IgG) was positive. Saliva sample confirmed the etiology of parotid virus with genotype N. The evolution was favorable and at 6-month follow-up, there were no sequelae. Given this clinical situation, information regarding the association and causality of this clinical entity and the MMR vaccine, focused on different strains of the mumps virus, was reviewed.
我们报告了一例既往无疾病史的大龄婴儿病例，该婴儿在接种麻疹、腮腺炎、风疹联合疫苗（MMR）约3周后，因发热症状、腮腺肿大及意识障碍而住院。诊断为无菌性脑膜炎，脑脊液检查发现细胞增多，以单核细胞为主，并通过分子生物学确认脑脊液中存在腮腺炎病毒。智利公共卫生研究所进行了一项研究，血清学检查（IgM和IgG）呈阳性。唾液样本确诊为N基因型腮腺炎病毒感染。病情进展良好，6个月随访时无后遗症。针对这一临床情况，我们回顾了关于这一临床实体与MMR疫苗之间关联及因果关系的信息，重点关注不同毒株的腮腺炎病毒。
