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接种 AZD1222 新冠疫苗后出现无菌性脑膜炎。

Aseptic meningitis following AZD1222 COVID-19 vaccination.

机构信息

School of Medicine, Department of Internal Medicine, Rasoul-E-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

School of Medicine, Department of Internal Medicine, Rasoul-E-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran; School of Medicine, Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Am J Emerg Med. 2022 May;55:225.e5-225.e6. doi: 10.1016/j.ajem.2021.12.035. Epub 2021 Dec 18.

DOI:10.1016/j.ajem.2021.12.035
PMID:34955313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8684093/
Abstract

The AZD1222 is one of the vaccines used against coronavirus disease 2019 (COVID-19), which is currently being used in many countries worldwide. Some important neurological side effects have been reported in association with this vaccine, but aseptic meningitis has not yet been reported. Herein, we report a case of aseptic meningitis in a 26-year-old health care worker, following the first dose of the AZD1222 vaccine.

摘要

AZD1222 是一种用于预防 2019 年冠状病毒病（COVID-19）的疫苗之一，目前在全球许多国家使用。该疫苗与一些重要的神经系统副作用有关，但尚未报告无菌性脑膜炎。在此，我们报告了一例 26 岁的医护人员在接种 AZD1222 疫苗第一针后发生无菌性脑膜炎的病例。

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本文引用的文献

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J Neuroimmunol. 2021 Oct 15;359:577691. doi: 10.1016/j.jneuroim.2021.577691. Epub 2021 Aug 8.
2
Aseptic meningitis after vaccination of the BNT162b2 mRNA COVID-19 vaccine.接种BNT162b2 mRNA新冠疫苗后发生的无菌性脑膜炎。
Neurol Sci. 2021 Nov;42(11):4433-4435. doi: 10.1007/s10072-021-05543-1. Epub 2021 Aug 11.
3
Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.疫苗接种后 COVID-19 疫苗诱导的免疫性血栓性血小板减少症和脑静脉窦血栓形成：系统评价。
J Neurol Sci. 2021 Sep 15;428:117607. doi: 10.1016/j.jns.2021.117607. Epub 2021 Aug 3.
4
[Cerebral venous sinus thrombosis after COVID-19 vaccination : Neurological and radiological management].[新冠疫苗接种后发生脑静脉窦血栓形成：神经学及影像学处理]
Radiologe. 2021 Oct;61(10):923-932. doi: 10.1007/s00117-021-00887-3. Epub 2021 Jul 29.
5
Postvaccinal Encephalitis after ChAdOx1 nCov-19.接种 ChAdOx1 nCov-19 后疫苗后脑炎。
Ann Neurol. 2021 Sep;90(3):506-511. doi: 10.1002/ana.26182. Epub 2021 Aug 13.
6
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7
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Rev Chilena Infectol. 2020 Dec;37(6):769-774. doi: 10.4067/S0716-10182020000600769.
8
Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein.血管内皮细胞损伤是 COVID-19 的核心部分，一种通过注射刺突蛋白 S1 亚单位诱导的小鼠模型。
Ann Diagn Pathol. 2021 Apr;51:151682. doi: 10.1016/j.anndiagpath.2020.151682. Epub 2020 Dec 24.
9
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Lancet. 2021 Dec 19;396(10267):1979-1993. doi: 10.1016/S0140-6736(20)32466-1. Epub 2020 Nov 19.
10
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Front Public Health. 2020 Jul 28;8:361. doi: 10.3389/fpubh.2020.00361. eCollection 2020.