Kang Han Sol, Kim Ju Eun, Yoo Jeong Rae, Oh Hyunjoo, Kim Misun, Kim Young Ree, Heo Sang Taek
Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Korea.
Department of Laboratory Medicine, College of Medicine, Jeju National University, Jeju, Korea.
Infect Chemother. 2022 Mar;54(1):189-194. doi: 10.3947/ic.2021.0131. Epub 2022 Jan 27.
Vaccines are one of the most important strategies against pandemics or epidemics involving infectious diseases. With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there have been global efforts for rapid development of coronavirus disease 2019 (COVID-19) vaccine and vaccination is being performed globally on a massive scale. With rapid increase in vaccination, rare adverse events have been reported. Well-known neurological adverse events associated with COVID-19 vaccination include Guillain-Barré syndrome, myelitis, and encephalitis. However, COVID-19 vaccine-related aseptic meningitis has rarely been reported. A 32-year-old healthy man visited our hospital with a complaint of headache for 1 week. He had received the second dose of the BNT162b2 mRNA COVID-19 vaccine 2 weeks before the onset of headache. Since the initial cerebrospinal fluid (CSF) profile suggested viral meningitis, we started treatment with an antiviral agent. However, the symptoms and follow-up CSF profile on day 7 of hospitalization showed no improvement and SARS-CoV-2 IgG antibodies were detected in the CSF. We suspected aseptic meningitis associated with the vaccination and intravenous methylprednisolone (500 mg/day) was administered for 3 days. The symptoms improved and the patient was discharged on day 12 of hospitalization.
疫苗是应对涉及传染病的大流行或流行病的最重要策略之一。随着严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的传播，全球都在努力快速研发2019冠状病毒病（COVID-19）疫苗，并且正在全球范围内大规模开展疫苗接种工作。随着疫苗接种的迅速增加，已经报告了一些罕见的不良事件。与COVID-19疫苗接种相关的众所周知的神经系统不良事件包括吉兰-巴雷综合征、脊髓炎和脑炎。然而，与COVID-19疫苗相关的无菌性脑膜炎鲜有报道。一名32岁的健康男性因头痛1周前来我院就诊。他在头痛发作前2周接种了第二剂BNT162b2 mRNA COVID-19疫苗。由于最初的脑脊液（CSF）检查结果提示病毒性脑膜炎，我们开始使用抗病毒药物进行治疗。然而，住院第7天的症状和后续脑脊液检查结果均无改善，且在脑脊液中检测到SARS-CoV-2 IgG抗体。我们怀疑是与疫苗接种相关的无菌性脑膜炎，并给予静脉注射甲泼尼龙（500毫克/天），持续3天。症状有所改善，患者于住院第12天出院。
