Huang Brian Z, Wang Songren, Bogumil David, Wilkens Lynne R, Wu Lang, Blot William J, Zheng Wei, Shu Xiao-Ou, Pandol Stephen J, Le Marchand Loïc, Setiawan Veronica Wendy
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Int J Cancer. 2021 Apr 12. doi: 10.1002/ijc.33598.
There is limited evidence on the association between red meat consumption and pancreatic cancer among ethnic minorities. We assessed this relationship in two large prospective cohorts: the Multiethnic Cohort Study (MEC) and the Southern Community Cohort Study (SCCS). Demographic, dietary and other risk factor data were collected at cohort entry. Red meat intake was assessed using cohort-specific validated food frequency questionnaires. Incident pancreatic cancer cases were identified via linkages to state cancer registries. Cox regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association of red meat intake with pancreatic cancer risk in each cohort. We performed additional analyses to evaluate cooking methods, mutagens and effect modification by NAT1/2 genotypes. From a total of 184 542 (MEC) and 66 793 (SCCS) at-risk participants, we identified 1618 (MEC) and 266 (SCCS) incident pancreatic cancer cases. Red meat consumption was associated with pancreatic cancer risk in the MEC (RR 1.18, 95% CI 1.02-1.37) and with borderline statistical significance in the SCCS (RR 1.31, 95% CI 0.93-1.86). This association was significant in African Americans (RR 1.49, 95% CI 1.06-2.11) and Latinos (RR 1.44, 95% CI 1.02-2.04) in the MEC, and among African Americans (RR 1.55, 95% CI 1.03-2.33) in the SCCS. NAT2 genotypes appeared to modify the relationship between red meat and pancreatic cancer in the MEC (p = 0.03). Our findings suggest that the associations for red meat may be strongest in African Americans and Latinos. The mechanisms underlying the increased risk for these populations should be further investigated.
关于少数族裔食用红肉与胰腺癌之间的关联，证据有限。我们在两个大型前瞻性队列中评估了这种关系：多族裔队列研究（MEC）和南方社区队列研究（SCCS）。在队列入组时收集了人口统计学、饮食及其他风险因素数据。使用特定队列经验证的食物频率问卷评估红肉摄入量。通过与州癌症登记处的关联确定胰腺癌发病病例。采用Cox回归计算每个队列中红肉摄入量与胰腺癌风险关联的相对风险（RR）和95%置信区间（CI）。我们进行了额外分析，以评估烹饪方法、诱变剂以及NAT1/2基因型的效应修饰。在总共184542名（MEC）和66793名（SCCS）有风险的参与者中，我们确定了1618例（MEC）和266例（SCCS）胰腺癌发病病例。在MEC中，红肉消费与胰腺癌风险相关（RR 1.18，95%CI 1.02 - 1.37），在SCCS中具有边缘统计学意义（RR 1.31，95%CI 0.93 - 1.86）。在MEC中，这种关联在非裔美国人（RR 1.49，95%CI 1.06 - 2.11）和拉丁裔（RR 1.44，95%CI 1.02 - 2.04）中显著，在SCCS中，在非裔美国人中（RR 1.55，95%CI 1.03 - 2.33）显著。NAT2基因型似乎改变了MEC中红肉与胰腺癌之间的关系（p = 0.03）。我们的研究结果表明，红肉的关联在非裔美国人和拉丁裔中可能最强。这些人群风险增加的潜在机制应进一步研究。
