Camargos P A, Guimaraes M D, Antunes C M
Department of Pediatrics, School of Medicine, Federal University of Minas Gerais State, Brazil.
Int J Epidemiol. 1988 Mar;17(1):193-7. doi: 10.1093/ije/17.1.193.
This case-control study was conducted to assess the risk, among children aged 0-12 years, of developing meningitis tuberculosis (MT) associated with a lack of intradermal BCG vaccination. Cases (45) of MT admitted for treatment at the Fundacao Benjamin Guimaraes Hospital (Belo Horizonte, MG, Brazil), from 1975 to 1981, were matched for age at hospitalization, date of hospitalization and nutritional status, with two types of controls--patients with acute diarrhoea (AD) and patients with acute non-tuberculous bacterial pneumonias (BP)--admitted to the same hospital. Vaccination status was ascertained from the patients' medical records. Results showed a risk for MT, estimated by the odds ratio, between BCG non-vaccinated and BCG vaccinated patients, of 6.7 (95% Cl 2.3-19.0) comparing cases and AD controls, of 4.0 (95% Cl 1.5-11.0) comparing cases and BP controls and 5.7 (95% Cl 2.3-14.0) comparing cases with both controls. When adjustments were made for place of residence (Metropolitan Region of Belo Horizonte and other regions of Minas Gerais State), the risks decreased to 5.2 (95% Cl 1.9-14.0) and 2.9 (95% Cl 1.2-7.3) comparing cases with AD and BP controls, respectively.
本病例对照研究旨在评估0至12岁儿童中，因未进行皮内卡介苗接种而患结核性脑膜炎（MT）的风险。1975年至1981年期间，在巴西米纳斯吉拉斯州贝洛奥里藏特市的本杰明·吉马良斯基金会医院接受治疗的45例MT病例，按照住院年龄、住院日期和营养状况，与两种类型的对照进行匹配——同一家医院收治的急性腹泻（AD）患者和急性非结核细菌性肺炎（BP）患者。通过患者的病历确定疫苗接种状况。结果显示，对于MT风险，以比值比估计，未接种卡介苗与接种卡介苗的患者相比，与AD对照比较时为6.7（95%可信区间2.3 - 19.0），与BP对照比较时为4.0（95%可信区间1.5 - 11.0），与两种对照比较时为5.7（95%可信区间2.3 - 14.0）。当对居住地点（贝洛奥里藏特市都会区和米纳斯吉拉斯州其他地区）进行调整后，与AD对照比较时风险降至5.2（95%可信区间1.9 - 14.0），与BP对照比较时风险降至2.9（95%可信区间1.2 - 7.3）。
