Thilothammal N, Krishnamurthy P V, Runyan D K, Banu K
Clinical Epidemiology Unit, Institute of Child Health and Hospital for Children, Madras, India.
Arch Dis Child. 1996 Feb;74(2):144-7. doi: 10.1136/adc.74.2.144.
The reported efficacy of BCG vaccine in preventing pulmonary tuberculosis varies from 0-80%; however, its efficacy in preventing tuberculous meningitis ranges from 52%-84%. A case-control study was conducted to assess the efficacy of BCG in preventing tuberculous meningitis in children. New cases of tuberculous meningitis, confirmed bacteriologically, were registered as cases. Controls were children suffering from febrile convulsions attending the same hospital. A total of 107 cases and 321 controls, block matched for age, were registered. Vaccination status was determined from the history reported by the mother and by BCG scar reading. Data regarding socioeconomic status, crowding, and nutritional status were collected. Using multiple logistic regression analysis the odds ratio obtained for the presence of BCG scar was 0.23 (95% confidence interval (CI) 0.14 to 0.37) and the protective efficacy of BCG vaccine in preventing tuberculous meningitis in children was found to be 77% (95% CI 71 to 83%).
据报道，卡介苗预防肺结核的有效率在0%至80%之间；然而，其预防结核性脑膜炎的有效率在52%至84%之间。开展了一项病例对照研究，以评估卡介苗在预防儿童结核性脑膜炎方面的效果。经细菌学确诊的结核性脑膜炎新病例被登记为病例。对照为在同一家医院就诊的热性惊厥儿童。共登记了107例病例和321名对照，按年龄进行了配比。根据母亲报告的病史和卡介苗疤痕检查确定疫苗接种状况。收集了有关社会经济地位、拥挤程度和营养状况的数据。使用多因素逻辑回归分析，卡介苗疤痕存在情况的比值比为0.23（95%置信区间（CI）为0.14至0.37），发现卡介苗预防儿童结核性脑膜炎的保护效力为77%（95%CI为71至83%）。
