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基于细菌纤维素的复合水凝胶在生物医学中的应用。

Biomedical Applications of Bacterial Cellulose based Composite Hydrogels.

机构信息

Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457,China.

Department of Chemical Engineering, Auburn University, Auburn, AL 36849,United States.

出版信息

Curr Med Chem. 2021;28(40):8319-8332. doi: 10.2174/0929867328666210412124444.

Abstract

BACKGROUND

Bacterial cellulose (BC) and its derivatives are a rich source of renewable natural ingredients, which are of great significance for biomedical and medical applications but have not yet been fully exploited. BC is a high-purity, biocompatible, and versatile biomaterial that can be used alone or in combination with other ingredients such as polymers and nanoparticles to provide different structural organization and function. This review briefly introduces the research status of BC hydrogels, focusing on the preparation of BC-based composite hydrogels and their applications in the field of biomedicine, particularly the wound dressings, tissue engineering scaffolds, and drug delivery.

METHODS

By reviewing the most recent literature on this subject, we summarized recent advances in the preparation of BC-based composite hydrogels and their advances in biomedical applications, including wound dressings, tissue engineering, and drug delivery.

RESULTS

BC composite hydrogels have broadened the field of application of BC and developed a variety of BC-based biomaterials with excellent properties. BC-based hydrogels have good biocompatibility and broad application prospects in the biomedical field.

CONCLUSION

BC-based composite hydrogels with the advantages of 3D structure, nontoxicity, high purity, and good biocompatibility, have great prospects in the development of sustainable and multifunctional biomaterials for biomedical applications.

摘要

背景

细菌纤维素(BC)及其衍生物是可再生天然成分的丰富来源,对生物医学和医疗应用具有重要意义,但尚未得到充分开发。BC 是一种高纯度、生物相容性和多功能的生物材料,可单独使用或与聚合物和纳米粒子等其他成分结合使用,以提供不同的结构组织和功能。本综述简要介绍了 BC 水凝胶的研究现状,重点介绍了基于 BC 的复合水凝胶的制备及其在生物医学领域的应用,特别是在伤口敷料、组织工程支架和药物输送方面的应用。

方法

通过回顾该主题的最新文献,我们总结了基于 BC 的复合水凝胶的制备及其在生物医学应用方面的最新进展,包括伤口敷料、组织工程和药物输送。

结果

BC 复合水凝胶拓宽了 BC 的应用领域,开发了多种具有优异性能的 BC 基生物材料。基于 BC 的水凝胶具有良好的生物相容性,在生物医学领域具有广阔的应用前景。

结论

具有 3D 结构、无毒、高纯度和良好生物相容性的基于 BC 的复合水凝胶在开发用于生物医学应用的可持续多功能生物材料方面具有广阔的前景。

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