Luo Chuan, Zhang Li, Ran Liyu, You Xuanhe, Huang Shishu
（ 610041） Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 Mar 20;55(2):243-248. doi: 10.12182/20240360507.
Bacterial cellulose (BC) is a type of extracellular polymeric nanomaterial secreted by microorganisms over the course of their growth. It has gained significant attention in the field of bone tissue engineering due to its unique structure of three-dimensional fibrous network, excellent biocompatibility, biodegradability, and exceptional mechanical properties. Nevertheless, BC still has some weaknesses, including low osteogenic activity, a lack of antimicrobial properties, small pore size, issues with the degradation rate, and a mismatch in bone tissue regeneration, limiting its standalone use in the field of bone tissue engineering. Therefore, the modification of BC and the preparation of BC composite materials have become a recent research focus. Herein, we summarized the relationships between the production, modification, and bone repair applications of BC. We introduced the methods for the preparation and the modification of BC. Additionally, we elaborated on the new advances in the application of BC composite materials in the field of bone tissue engineering. We also highlighted the existing challenges and future prospects of BC composite materials.
细菌纤维素（BC）是微生物在生长过程中分泌的一种细胞外聚合纳米材料。由于其独特的三维纤维网络结构、优异的生物相容性、生物降解性和卓越的机械性能，它在骨组织工程领域受到了广泛关注。然而，BC仍然存在一些弱点，包括成骨活性低、缺乏抗菌性能、孔径小、降解速率问题以及与骨组织再生不匹配等，这限制了其在骨组织工程领域的单独应用。因此，BC的改性和BC复合材料的制备已成为近期的研究热点。在此，我们总结了BC的生产、改性与骨修复应用之间的关系。我们介绍了BC的制备和改性方法。此外，我们阐述了BC复合材料在骨组织工程领域应用的新进展。我们还强调了BC复合材料目前存在的挑战和未来前景。
