The University of Texas at Austin, Nutritional Sciences School of Human Ecology, 200 W. 24th Street, GEA 331, Austin, TX78712, USA.
Division of Geriatrics, Gerontology & Palliative Medicine and the Sam & Ann Barshop Institute for Longevity & Aging Studies, Department of Medicine, UT Health San Antonio, San Antonio, TX, USA.
Public Health Nutr. 2022 Jan;25(1):82-89. doi: 10.1017/S1368980021001609. Epub 2021 Apr 13.
The aims of this study were to examine the efficacy among various vitamin D supplementation regimens on serum 25-hydroxyvitamin D (25(OH)D) concentrations and determine the minimal dose rate required to achieve sufficient serum concentrations (≥75 nmol/l) among older adults in long-term care (LTC).
A 1-year medical history was abstracted from medical records, and a one-time blood draw to measure serum 25(OH)D concentrations was obtained. Individuals were stratified into vitamin D-supplemented and non-supplemented groups. The supplemented group was further categorised into four treatment forms: single-ingredient vitamin D2or3, multivitamin, Ca with vitamin D or combination of the three, and by daily prescribed doses: 0-9·9, 10-19·9, 20-49·9, 50-99·9 and >100 μg/d.
Five LTC communities in Austin, Texas.
One hundred seventy-three older (≥65 years) adults.
Of the participants, 62% received a vitamin D supplement and 55% had insufficient (≤75 nmol/l) 25(OH)D serum concentrations. Individuals receiving single-ingredient vitamin D2or3 supplementation received the highest daily vitamin D mean dose (72·5 μg/d), while combination of forms was the most frequent treatment (44%) with the highest mean serum concentration (108 nmol/l). All supplementation doses were successful at reaching sufficient serum concentrations, except those<20 μg/d. Using a prediction model, it was observed that 0·025 μg/d of vitamin D supplementation resulted in a 0·008 nmol/l increase in serum 25(OH)D concentrations.
Based on the predictive equation, results suggest that supplementation of 37·5 μg/d of vitamin D2or3 or combination of vitamin D is most likely to achieve sufficient serum 25(OH)D concentrations in older adults in LTC.
本研究旨在考察各种维生素 D 补充方案对血清 25-羟维生素 D（25（OH）D）浓度的疗效，并确定长期护理（LTC）中老年人达到足够血清浓度（≥75nmol/L）所需的最小剂量率。
从病历中提取了 1 年的医疗史，并进行了一次单次采血以测量血清 25（OH）D 浓度。将个体分为维生素 D 补充组和非补充组。补充组进一步分为四种治疗形式：单一成分维生素 D2 或 D3、多种维生素、钙加维生素 D 或三者的组合，并按每日规定剂量分类：0-9.9、10-19.9、20-49.9、50-99.9 和>100μg/d。
德克萨斯州奥斯汀的五个 LTC 社区。
173 名年龄≥65 岁的老年人。
在参与者中，62%接受了维生素 D 补充剂，55%的人血清 25（OH）D 浓度不足（≤75nmol/L）。接受单一成分维生素 D2 或 D3 补充剂的个体接受了最高的每日维生素 D 平均剂量（72.5μg/d），而组合形式是最常见的治疗方法（44%），平均血清浓度最高（108nmol/L）。所有补充剂量都成功达到了足够的血清浓度，除了那些<20μg/d 的剂量。使用预测模型观察到，每天补充 0.025μg 的维生素 D 会使血清 25（OH）D 浓度增加 0.008nmol/L。
基于预测方程，结果表明，LTC 中老年人每天补充 37.5μg 的维生素 D2 或 D3 或维生素 D 组合最有可能达到足够的血清 25（OH）D 浓度。
