National Neuroimaging Facility, National Brain Research Centre, Manesar, Haryana, India.
Center for Cognitive and Brain Sciences, Indian Institute of Technology Gandhinagar, Gujarat, India.
Can J Neurol Sci. 2022 Mar;49(2):282-286. doi: 10.1017/cjn.2021.64. Epub 2021 Apr 13.
Corpus callosum (CC) is the primary fiber system bridging the cerebral hemispheres and is of critical importance for glioma migration which downgrades the prognosis. Here we present the specific pattern of CC restructuring in glioma patients. We probe that the magnetic resonance imaging-based fiber count decrease can be a ready noninvasive indicator of glioma aggressivity and prognosis. We find that to maintain the callosal neural transmission efficiency, the optimum architectural density of white matter fibers remains unchanged, even though there is gross fiber loss. This adaptation occurs by CC's isotonic restructuration, a protective compensatory behavior for maintaining CC's optimal functional efficiency despite malignant infiltration.
胼胝体（CC）是连接大脑半球的主要纤维系统，对于降低预后的胶质瘤迁移至关重要。在这里，我们展示了胶质瘤患者 CC 重构的特定模式。我们探讨了基于磁共振成像的纤维计数减少是否可以成为胶质瘤侵袭性和预后的一种现成的无创指标。我们发现，为了保持胼胝体神经传递效率，白质纤维的最佳结构密度保持不变，即使存在明显的纤维丢失。这种适应是通过 CC 的等张重构发生的，这是一种保护代偿行为，用于维持 CC 的最佳功能效率，尽管存在恶性浸润。
