青少年骨密度与 VCTE 定量肝脂肪变性程度之间的倒 U 型关系：来自 NHANES 的证据。
Inverted U-shaped relationships between bone mineral density and VCTE-quantified degree of hepatic steatosis in adolescents: Evidence from the NHANES.
机构信息
Department of Hand and Foot Surgery, The Affiliated Second Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Department of Traumatic and Pediatric Orthopedics, The Affiliated Second Hospital, Hengyang Medical School, University of South China, Hengyang, China.
出版信息
PLoS One. 2023 Jun 9;18(6):e0286688. doi: 10.1371/journal.pone.0286688. eCollection 2023.
INTRODUCTION
There may be inaccuracies in hepatic steatosis in past research assessing the relationship between bone metabolism and liver steatosis. The goal of the current research was to look at the associations between bone mineral density (BMD) and the hepatic steatosis and fibrosis as detected by vibration-controlled transient elastography (VCTE) in teenagers in the United States.
METHODS
Weighted multiple linear regression models and smoothed curve fitting were used to investigate the association between BMD and the degree of hepatic steatosis and fibrosis in adolescents.
RESULTS
In 829 adolescents aged 12-19 years we found a negative association between total BMD and CAP (controlled attenuation parameter) [-32.46 (-58.98, -9.05)] and a significant positive association between lumbar BMD and LSM (liver stiffness measurement) [1.35 (0.19, 2.51)]. The inverted U-shaped relationships were founded between total BMD, lumbar BMD, pelvis BMD, and CAP with inflection points of 221.22 dB/m, 219.88 dB/m, and 216.02 dB/m, respectively.
CONCLUSIONS
In adolescents, higher BMD is significantly associated with lower levels of hepatic steatosis and higher levels of liver stiffness.
简介
在过去评估骨代谢与肝脂肪变性之间关系的研究中，肝脂肪变性可能存在不准确性。本研究的目的是观察美国青少年骨密度（BMD）与通过振动控制瞬态弹性成像（VCTE）检测到的肝脂肪变性和纤维化之间的关联。
方法
使用加权多元线性回归模型和平滑曲线拟合来研究青少年的 BMD 与肝脂肪变性和纤维化程度之间的关联。
结果
在 829 名 12-19 岁的青少年中，我们发现总 BMD 与 CAP（受控衰减参数）呈负相关[-32.46（-58.98，-9.05)]，而腰椎 BMD 与 LSM（肝硬度测量）呈显著正相关[1.35（0.19，2.51)]。总 BMD、腰椎 BMD、骨盆 BMD 与 CAP 之间存在倒 U 型关系，拐点分别为 221.22 dB/m、219.88 dB/m 和 216.02 dB/m。
结论
在青少年中，较高的 BMD 与较低的肝脂肪变性水平和较高的肝硬度水平显著相关。
Zotero 插件