Anwar Majid, Muhammad Faqir, Akhtar Bushra, Anwar Muhammad Irfan, Raza Ahmad, Aleem Abdul
Institute of Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan.
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan.
Int J Pept Res Ther. 2021;27(3):1689-1697. doi: 10.1007/s10989-021-10201-3. Epub 2021 Apr 8.
Nanoformulations are novel therapeutic strategies as compared to traditional treatments. The development of biomimetic nanoparticles by combining the natural cellular material with synthetic nanoparticles has inspired innovative vaccine strategies for modifying the antibacterial immunity. A lot of work has been done in which synthetic nanoparticles are coated with biomimetic cellular membranes for enhancement of biological functions and treatments. Outer membrane protein of bacteria not only act as adjuvant but also contain a large number of immunogenic antigens that play an important role in motivating the native immunity and stimulating the immune responses of the body. Outer membrane protein coating onto the surfaces of synthetic nanoparticles has synergistic effects to produce antibacterial responses. This article reviews the recent improvements related to the bacterial membrane-coated nanoparticles for antibacterial immunization.
与传统治疗方法相比，纳米制剂是一种新型治疗策略。将天然细胞材料与合成纳米颗粒相结合来开发仿生纳米颗粒，激发了用于调节抗菌免疫的创新疫苗策略。人们已经开展了大量工作，将合成纳米颗粒包覆上仿生细胞膜以增强生物学功能和治疗效果。细菌外膜蛋白不仅可作为佐剂，还含有大量免疫原性抗原，这些抗原在激发天然免疫和刺激机体免疫反应中发挥重要作用。在合成纳米颗粒表面包覆外膜蛋白具有协同效应，可产生抗菌反应。本文综述了与用于抗菌免疫的细菌膜包覆纳米颗粒相关的最新进展。
