Department of NanoEngineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA.
Vaccines (Basel). 2015 Oct 6;3(4):814-28. doi: 10.3390/vaccines3040814.
Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation.
纳米颗粒在增强免疫疗法效力方面表现出独特的优势，并且在开发安全有效的疫苗制剂方面引起了越来越多的关注。最近的技术进步导致了细胞膜包覆的纳米颗粒的发现和发展，这些纳米颗粒结合了细胞膜的丰富功能和合成纳米材料的工程灵活性。这种新型仿生纳米颗粒激发了具有强大调节抗菌免疫潜力的新型疫苗设计策略。本文将综述利用细胞膜包覆的纳米颗粒进行抗菌疫苗接种的最新进展。具体而言，将讨论两种主要的开发策略，即（i）通过细菌毒素隔离进行针对毒力因子的疫苗接种；以及（ii）通过模拟细菌抗原呈递进行针对病原体的疫苗接种。
Zotero 插件
