Department of Urology, The First Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Department of Urology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
Int J Mol Med. 2021 Jun;47(6). doi: 10.3892/ijmm.2021.4932. Epub 2021 Apr 13.
Bladder cancer (BC) is among the most common urinary system tumors with a high morbidity and mortality worldwide. Despite advancements being made in the diagnosis and treatment of bladder cancer, targeted therapy remains the most promising treatment, and novel therapeutic targets are urgently required in to improve the outcomes of patients with BC. Kinesin family member 4A (KIF4A) is a plus‑end directed motor protein involved in the regulation of multiple cellular processes, such as mitosis and axon growth. Notably, KIF4A plays important roles in tumor growth and progression, and its expression is associated with the prognosis of several types of cancer. However, the potential role and molecular mechanisms of KIF4A in bladder cancer development remain unclear. The present study demonstrated that KIF4A was highly expressed in human BC tissues, and its expression was associated with patient clinicopathological characteristics, such as tumor stage (P=0.012) and with the prognosis of patients with BC. It was further found that KIF4A promoted the cell proliferation of bladder cancer both and . On the whole, the data presented herein provide evidence that KIF4A promotes the development of BC through the transcriptional activation of the expression of CDCA3. The present study indicates the involvement of KIF4A in the progression of BC and suggests that KIF4A may be a promising therapeutic target for the treatment of BC.
膀胱癌 (BC) 是最常见的泌尿系统肿瘤之一，在全球范围内具有较高的发病率和死亡率。尽管在膀胱癌的诊断和治疗方面取得了进展，但靶向治疗仍然是最有前途的治疗方法，迫切需要新的治疗靶点来改善 BC 患者的预后。驱动蛋白家族成员 4A（KIF4A）是一种正向末端定向的马达蛋白，参与调节多种细胞过程，如有丝分裂和轴突生长。值得注意的是，KIF4A 在肿瘤生长和进展中发挥着重要作用，其表达与几种癌症的预后相关。然而，KIF4A 在膀胱癌发展中的潜在作用和分子机制尚不清楚。本研究表明，KIF4A 在人膀胱癌组织中高表达，其表达与患者的临床病理特征相关，如肿瘤分期（P=0.012）和膀胱癌患者的预后。进一步研究发现，KIF4A 通过转录激活 CDCA3 的表达促进膀胱癌细胞的增殖。综上所述，本文数据提供了证据表明，KIF4A 通过转录激活 CDCA3 的表达促进 BC 的发展。本研究表明 KIF4A 参与了 BC 的进展，并提示 KIF4A 可能成为治疗 BC 的有前途的治疗靶点。
