Xia Haoran, Wang Miaomiao, Su Xiaonan, Lv Zhengtong, Yan Qiuxia, Guo Xiaoxiao, Liu Ming
Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Front Mol Biosci. 2022 Apr 13;9:838654. doi: 10.3389/fmolb.2022.838654. eCollection 2022.
The effect of the adenoviral early region 2 binding factors (E2Fs) target pathway on prostate cancer is not clear. It is necessary to establish an E2F target-related gene signature to predict prognosis and facilitate clinical decision-making. An E2F target-related gene signature was established by univariate and LASSO Cox regression analyses, and its predictive ability was verified in multiple cohorts. Moreover, the enrichment pathway, immune microenvironment, and drug sensitivity of the activated E2F target pathway were also explored. The E2F target-related gene signature consisted of , , , and . The patients with high-risk scores showed poor prognosis, therapeutic resistance, and immunosuppression, along with abnormal growth characteristics of cells. Tinib drugs showed high sensitivity to the expression of and genes. Our research established an E2F target-related signature for predicting the prognosis of prostate cancer. This study provides insights into formulating individualized detection and treatment as well as provides a theoretical basis for future research.
腺病毒早期区域2结合因子（E2Fs）靶向通路对前列腺癌的影响尚不清楚。有必要建立一个与E2F靶点相关的基因特征来预测预后并促进临床决策。通过单变量和LASSO Cox回归分析建立了一个与E2F靶点相关的基因特征，并在多个队列中验证了其预测能力。此外，还探讨了激活的E2F靶点通路的富集途径、免疫微环境和药物敏感性。与E2F靶点相关的基因特征由 、 、 和 组成。高危评分患者预后较差、具有治疗抗性和免疫抑制，同时伴有细胞生长特征异常。替尼类药物对 和 基因的表达表现出高敏感性。我们的研究建立了一个用于预测前列腺癌预后的与E2F靶点相关的特征。本研究为制定个体化检测和治疗提供了见解，并为未来的研究提供了理论基础。
