Bioaccessibility of Cd and its Correlation with Divalent Mineral Nutrients in Locally Grown Rice from Two Provinces in China.

Rice and rice products are the main sources of Cd contamination in humans. The total and bioaccessible concentrations of Cd and three divalent nutrients, Mn, Cu, and Zn, in locally grown rice grains from Hunan and Guangdong Provinces in China were investigated. An in vitro physiologically based extraction test method was introduced to evaluate the bioaccessibility of the target metals in the rice grains. The mean concentrations of Cd in the rice grains were 0.245 mg/kg and 0.235 mg/kg from Hunan and Guangdong Provinces, respectively. Large variations were observed in the Cd concentrations, indicating a heterogeneous distribution of Cd contamination throughout the study areas. The bioaccessibility of Cd, Mn, and Zn in the gastrointestinal fractions was significantly lower than that in the gastric fractions. In contrast, the bioaccessibility of Cu at the intestinal phase was detected in the rice grains from both provinces. The correlation analysis showed significant relationships between total Cd concentrations and bioaccessible Cd fractions, indicating that higher total Cd in rice grains always resulted in higher bioaccessible Cd. Consistent correlations in the rice grains were observed between Zn and Mn. However, a lack of correlation was found between Cd and Zn in the current study. Risk assessment according to bioaccessible Cd would significantly reduce the exposure risk to Cd from rice consumption.