Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Future Microbiol. 2021 Apr;16:445-452. doi: 10.2217/fmb-2020-0092. Epub 2021 Apr 13.
Influenza A virus (IAV) is a crucial cause of respiratory infections in humans worldwide. Therefore, studies should clarify adaptation mechanisms of IAV and critical factors of the viral pathogenesis in human hosts. GTPases of the Rab family are the largest branch of the Ras-like small GTPase superfamily, and they regulate almost every step during vesicle-mediated trafficking. Evidence has shown that Rab proteins participate in the lifecycle of IAV. In this mini-review, we outline the regulatory mechanisms of different Rab proteins in the lifecycle of IAV. Understanding the role of Rab proteins in IAV infections is important to develop broad-spectrum host-targeted antiviral strategies.
甲型流感病毒（IAV）是全球人类呼吸道感染的重要病因。因此，研究应阐明 IAV 的适应机制和人类宿主中病毒发病机制的关键因素。Rab 家族 GTPases 是 Ras 样小 GTPase 超家族中最大的分支，它们调节囊泡介导的运输过程中的几乎每一步。有证据表明 Rab 蛋白参与了 IAV 的生命周期。在这篇综述中，我们概述了不同 Rab 蛋白在 IAV 生命周期中的调控机制。了解 Rab 蛋白在 IAV 感染中的作用对于开发广谱的宿主靶向抗病毒策略很重要。
