Instituto de Biomedicina, Ministerio para la Salud, Universidad Central de Venezuela, Caracas, Venezuela.
Exp Dermatol. 2021 Jul;30(7):982-987. doi: 10.1111/exd.14351. Epub 2021 Apr 13.
Innate lymphoid cells (ILCs) are classified by the expression of specific transcription factors: ILC1 depending on T-bet for IFN-γ production; ILC2 depending on GATA3 for IL-5 and IL-13; and ILC3 depending on ROR-γτ and AHR for IL-17 and IL-22. This study aimed to determine circulating ILCs in 23 patients with localized (LCL) = 7, mucocutaneous (MCL) = 10, intermediate (ICL) = 3 and diffuse (DCL) = 3 cutaneous leishmaniasis and 17 healthy controls from endemic area (EC) = 9 and non-endemic area (HC) = 8. Results evidenced a higher proportion of ILC1 in LCL than controls and MCL. ILC2 was higher in DCL compared with controls. ILC3 s were abundant in MCL and DCL concerning controls. A prevalence ratio was calculated to approach cell plasticity: in LCL, the ratio showed a prevalence of ILC1/ILC3 (plasticity 1), in contrast to DCL, and controls, where ILC2/ILC3 (plasticity 3) is prevalent. Also, MCL and ICL showed higher ILC1/ILC2 (plasticity 2). These results suggest that ILC1 and ILC3 in LCL are associated with disease control and regulation of inflammation, while MCL and ICL are related to immunopathology and uncontrolled inflammation. In DCL, ILC2 is associated with the tolerogenic state of these patients.
固有淋巴细胞（ILC）根据特定转录因子的表达进行分类：ILC1 取决于 T-bet 产生 IFN-γ；ILC2 取决于 GATA3 产生 IL-5 和 IL-13；ILC3 取决于 ROR-γt 和 AHR 产生 IL-17 和 IL-22。本研究旨在确定 23 例局限性（LCL）= 7、黏膜皮肤性（MCL）= 10、中间型（ICL）= 3 和弥漫性（DCL）= 3 皮肤利什曼病患者和 17 例来自流行地区（EC）= 9 和非流行地区（HC）= 8 的健康对照者的循环 ILC。结果表明，LCL 患者中 ILC1 的比例高于对照组和 MCL。与对照组相比，DCL 中 ILC2 较高。与对照组相比，MCL 和 DCL 中 ILC3 更为丰富。计算了患病率比值以探讨细胞可塑性：在 LCL 中，该比值显示 ILC1/ILC3（可塑性 1）的患病率较高，而 DCL 和对照组则显示 ILC2/ILC3（可塑性 3）的患病率较高。此外，MCL 和 ICL 显示出更高的 ILC1/ILC2（可塑性 2）。这些结果表明，LCL 中的 ILC1 和 ILC3 与疾病控制和炎症调节有关，而 MCL 和 ICL 则与免疫病理学和不受控制的炎症有关。在 DCL 中，ILC2 与这些患者的耐受状态有关。
