Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
Medicine (Baltimore). 2021 Apr 16;100(15):e25483. doi: 10.1097/MD.0000000000025483.
Emerging evidence has indicated that interleukin-8 (IL-8) gene-251A/T polymorphism may affect individual susceptibility to sepsis. However, the results of published studies are inconclusive. The aim of this meta-analysis was to elucidate the association between this polymorphism and the risk and mortality of sepsis.
Relevant publications were searched from PubMed, EmBase, and Web of Science databases up to January 31, 2021, with studies only in English. The reference lists of the retrieved studies were investigated as well. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to figure out the relationship between IL-8-251 A/T polymorphisms and the risk and mortality of sepsis. All of the data were analyzed with Stata 16.0.
The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.
This meta-analysis will summarize the relationship between IL-8-251 A/T polymorphism and the risk and mortality of sepsis.
新出现的证据表明，白细胞介素-8（IL-8）基因-251A/T 多态性可能影响个体对败血症的易感性。然而，已发表研究的结果尚无定论。本荟萃分析的目的是阐明这种多态性与败血症的风险和死亡率之间的关系。
检索了截至 2021 年 1 月 31 日PubMed、Embase 和 Web of Science 数据库中的相关文献，仅纳入英文文献。还调查了检索研究的参考文献列表。采用 Stata 16.0 计算合并优势比（OR）及其 95%置信区间（CI），以确定 IL-8-251A/T 多态性与败血症的风险和死亡率之间的关系。
本荟萃分析的结果将提交给同行评审的期刊发表。
本荟萃分析将总结 IL-8-251A/T 多态性与败血症的风险和死亡率之间的关系。
