经皮冠状动脉介入治疗后糖尿病患者支架内再狭窄的危险因素：系统评价和荟萃分析方案。
Risk factors of in-stent restenosis in patients with diabetes mellitus after percutaneous coronary intervention: A protocol for systematic review and meta-analysis.
机构信息
Department of Endocrinology.
Department of Neurology.
出版信息
Medicine (Baltimore). 2021 Apr 16;100(15):e25484. doi: 10.1097/MD.0000000000025484.
BACKGROUND
Percutaneous coronary intervention (PCI) has become one of the effective methods for the treatment of coronary heart disease (CHD). However, it is easy to have in-stent restenosis (ISR), even cardiovascular events after PCI, which affects the therapeutic effects. The incidence of ISR in diabetes mellitus (DM) patients increased by 2 to 4 times. Early identification of the risk factors of ISR in DM patients after PCI may help clinical staff to prevent and intervene as soon as possible, so it is very important to improve the clinical outcomes of DM patients. Although scholars at home and abroad have studied and summarized the risk factors of ISR in DM patients after PCI, the conclusions are different. Therefore, in this study, meta-analysis was used to summarize the risk factors of ISR in DM patients after PCI, and to explore the characteristics of high-risk groups of ISR, thus providing reference for early identification and prevention of ISR.
METHODS
We will search related literature from PubMed, Embase, Cochrane Library, Web of Science, China Biology Medicine Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Eligible studies will be screened based on inclusion criteria. Meanwhile, data extraction, risk of bias assessment, publication bias assessment, subgroup analysis, and quality assessment will be performed. Review Manager Version 5.3 software will be applied for data analysis. Each process is independently conducted by 2 researchers. If there is any objection, it will be submitted to a third researcher for resolution.
RESULTS
We will disseminate the findings of this systematic review and meta-analysis via publications in peer-reviewed journals.
CONCLUSIONS
The results of this analysis can be used to generate a risk prediction model and provide an intervention strategy for the occurrence of ISR in DM patients after PCI.
OSF REGISTRATION NUMBER
DOI 10.17605/OSF.IO/WC87Y.
背景
经皮冠状动脉介入治疗（PCI）已成为治疗冠心病（CHD）的有效方法之一。然而，它很容易发生支架内再狭窄（ISR），甚至在 PCI 后发生心血管事件，这会影响治疗效果。糖尿病（DM）患者的 ISR 发生率增加了 2 到 4 倍。早期识别 PCI 后 DM 患者 ISR 的危险因素，可能有助于临床工作人员尽快进行预防和干预，因此提高 DM 患者的临床转归非常重要。尽管国内外学者对 PCI 后 DM 患者 ISR 的危险因素进行了研究和总结，但结论不尽相同。因此，本研究采用 Meta 分析对 PCI 后 DM 患者 ISR 的危险因素进行总结，探讨 ISR 高危人群的特点，为 ISR 的早期识别和预防提供参考。
方法
我们将从 PubMed、Embase、Cochrane 图书馆、Web of Science、中国生物医学文献数据库、中国知网、中国科技期刊数据库和万方数据库中检索相关文献。根据纳入标准筛选合格文献，并进行数据提取、偏倚风险评估、发表偏倚评估、亚组分析和质量评价。采用 Review Manager Version 5.3 软件进行数据分析。每个过程均由 2 位研究者独立进行。如果有任何异议，将提交给第 3 位研究者解决。
结果
我们将通过在同行评议期刊上发表来传播这项系统评价和 Meta 分析的研究结果。
结论
该分析结果可用于生成风险预测模型，并为 PCI 后 DM 患者 ISR 的发生提供干预策略。
OSF 注册号：DOI 10.17605/OSF.IO/WC87Y。
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