Itani Malak, Lalwani Neeraj, Ganeshan Dhakshinamoorthy, Zulfiqar Maria, Siegel Cary
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Abdom Radiol (NY). 2021 Jun;46(6):2281-2292. doi: 10.1007/s00261-020-02911-x. Epub 2021 Apr 13.
More than one-fifth of ovarian cancers are hereditary, with most of them caused by BRCA genes. Malignant ovarian neoplasms are primarily epithelial tumors, a heterogeneous group of tumors with variable genetic backgrounds that translate into different biologic behaviors and morphologic features. Radiologists play an increasingly important role in the diagnosis and management of oncology patients. Familiarity with hereditary ovarian cancers will have a positive impact on patient management and radiologists' involvement in the multidisciplinary approach needed for this delicate patient population. In this paper, we review the basic histologic and genetic backgrounds of ovarian tumors with an emphasis on hereditary ovarian cancers, as well as the effects that these factors have on patient workup, primarily with regard to imaging studies.
超过五分之一的卵巢癌具有遗传性，其中大多数由BRCA基因引起。恶性卵巢肿瘤主要是上皮性肿瘤，这是一组具有不同遗传背景的异质性肿瘤，这些遗传背景导致不同的生物学行为和形态学特征。放射科医生在肿瘤患者的诊断和管理中发挥着越来越重要的作用。熟悉遗传性卵巢癌将对患者管理以及放射科医生参与针对这一特殊患者群体所需的多学科方法产生积极影响。在本文中，我们回顾了卵巢肿瘤的基本组织学和遗传背景，重点是遗传性卵巢癌，以及这些因素对患者检查的影响，主要涉及影像学研究。
