Nakamura K, Inagaki F, Tamai Y
Department of Biochemistry, Kitasato University School of Medicine, Kanagawa, Japan.
J Biol Chem. 1988 Jul 15;263(20):9896-900.
A novel trisialoganglioside has been isolated from dogfish (Squalus acanthias) brain. From the results of gas chromatography-mass spectrometric analysis of methylated sugars, enzymatic hydrolysis, fast atom bombardment mass spectrometry, and proton nuclear magnetic resonance analysis, its structure was concluded to be (formula; see text) This is the first report of the occurrence of a ganglioside with 3 sialic acid residues separately linked to its gangliotetraosyl backbone.
