从旋覆花中分离得到的新穿心莲内酯 A 和 B 及其抗炎活性。
Neolinulicin A and B from Inula japonica and their anti-inflammatory activities.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, People's Republic of China.
出版信息
Fitoterapia. 2021 Jul;152:104905. doi: 10.1016/j.fitote.2021.104905. Epub 2021 Apr 10.
A phytochemical study performed on Inula japonica led to isolation of a new 1,10-seco-sesquiterpene dimer Neolinulicin A (1) and 1,10-seco-sesquiterpene Neolinulicin B (2), together with nine known sesquiterpenes (3-11). Among them, Neolinulicin A (1), which has a new carbon skeleton, was a Diels-Alder [4 + 2] adduct of two sesquiterpene moieties. Their structures were established by extensive spectroscopic analysis. All of the isolated compounds showed inhibition of NO production in RAW 264.7 macrophages. The findings might supply information for the future design of anti-inflammatory agents from I. japonica.
对旋覆花进行的植物化学研究导致分离得到了一种新的 1,10-二萜二聚体 Neolinulicin A（1）和 1,10-二萜 Neolinulicin B（2），以及 9 种已知的倍半萜（3-11）。其中，具有新碳骨架的 Neolinulicin A（1）是两个倍半萜部分的 Diels-Alder [4+2]加合物。通过广泛的光谱分析确定了它们的结构。所有分离得到的化合物均显示对 RAW 264.7 巨噬细胞中 NO 产生的抑制作用。这些发现可能为未来从旋覆花中设计抗炎剂提供信息。
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