Dourado Douglas, Freire Danielle T, Pereira Daniel T, Amaral-Machado Lucas, N Alencar Éverton, de Barros André Luís Branco, Egito E Sócrates T
Graduate Program in Pharmaceutical Nanotechnology, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil; Dispersed Systems Laboratory (LaSiD), Pharmacy Department, UFRN, Natal, Brazil.
Dispersed Systems Laboratory (LaSiD), Pharmacy Department, UFRN, Natal, Brazil.
Biomed Pharmacother. 2021 Jul;139:111578. doi: 10.1016/j.biopha.2021.111578. Epub 2021 Apr 6.
The COVID-19 has become of striking interest since the number of deaths is constantly rising all over the globe, and the search for an efficient treatment is more urgent. In light of this worrisome scenario, this opinion review aimed to discuss the current knowledge about the potential role of curcumin and its nanostructured systems on the SARS-CoV-2 targets. From this perspective, this work demonstrated that curcumin urges as a potential antiviral key for the treatment of SARS-CoV-2 based on its relation to the infection pathways. Moreover, the use of curcumin-loaded nanocarriers for increasing its bioavailability and therapeutic efficiency was highlighted. Additionally, the potential of the nanostructured systems by themselves and their synergic action with curcumin on molecular targets for viral infections have been explored. Finally, a viewpoint of the studies that need to be carried out to implant curcumin as a treatment for COVID-19 was addressed.
自全球死亡人数不断上升以来，新型冠状病毒肺炎（COVID-19）已引起人们极大的关注，寻找有效的治疗方法变得更加紧迫。鉴于这种令人担忧的情况，本观点综述旨在讨论姜黄素及其纳米结构系统在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）靶点上潜在作用的现有知识。从这个角度来看，这项工作表明，基于姜黄素与感染途径的关系，它有望成为治疗SARS-CoV-2的潜在抗病毒关键药物。此外，还强调了使用负载姜黄素的纳米载体来提高其生物利用度和治疗效果。此外，还探讨了纳米结构系统本身的潜力及其与姜黄素在病毒感染分子靶点上的协同作用。最后，阐述了为将姜黄素作为COVID-19的治疗方法而需要开展的研究观点。
