Li Chunzhu, Xing Chuan, Zhang Jiaqi, Zhao Han, Shi Wenjing, He Bing
Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning, China.
J Transl Med. 2021 Apr 13;19(1):148. doi: 10.1186/s12967-021-02817-2.
Time-restricted feeding (TRF) is a form of intermittent fasting, which is beneficial for weight loss and cardiometabolic health. Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine and metabolic diseases affecting women of childbearing age. It is associated with an increased prevalence of metabolic syndrome, cardiovascular diseases and type 2 diabetes. The effects of TRF on PCOS patients remains undefined, here we investigated the impact of TRF on women with anovulatory PCOS.
Eighteen PCOS women aged between 18 and 31 with anovulation participated in a 6-week trial which were divided into two consecutive periods: (1) 1-week baseline weight stabilization period and (2) 5-week TRF period. Fifteen participants completed the study. Changes in body weight, body mass index (BMI), Waist-to-Hip Ratio, skeletal muscle mass, body fat mass (BFM), body fat percentage (BF%), visceral fat area (VFA), luteinizing hormone (LH), follicle-stimulating hormone (FSH), LH/FSH, total testosterone (TT), sex hormone-binding globulin (SHBG), free androgen index (FAI), fasting glucose, fasting insulin (FINS), homeostasis model assessment-insulin resistance (HOMA-IR), area under the curve (AUC) for insulin (AUCIns), area under the curve (AUC) for glucose (AUCGlu), AUCIns/AUCGlu Ratio, lipids, uric acid, alanine aminotransferase (ALT), aspartate aminotransferase, high-sensitivity C-reactive protein (hsCRP), insulin-like growth factor (IGF-1), menstrual cycle and eating behaviors were evaluated.
Significant changes in body weight, BMI, BFM, BF%, VFA, TT, SHBG, FAI, FINS, HOMA-IR, AUCIns, AUCIns/AUCGlu Ratio, ALT, hsCRP and IGF-1 were found after the TRF period. An improvement in menstrual cycle irregularity was detected in 73.3% (11/15) patients.
The diet of TRF may be beneficial to anovulatory PCOS on weight loss especially reducing body fat, improving menstruation, hyperandrogenemia, insulin resistance and chronic inflammation. Trial registration Clinicaltrial.gov, NCT04580433, registered October 8, 2020, https://clinicaltrials.gov/ct2/show/NCT04580433.
限时进食（TRF）是间歇性禁食的一种形式，对体重减轻和心脏代谢健康有益。多囊卵巢综合征（PCOS）是影响育龄女性的最常见的生殖内分泌和代谢疾病之一。它与代谢综合征、心血管疾病和2型糖尿病的患病率增加有关。TRF对PCOS患者的影响尚不清楚，在此我们研究了TRF对无排卵性PCOS女性的影响。
18名年龄在18至31岁之间的无排卵PCOS女性参加了一项为期6周的试验，该试验分为两个连续阶段：（1）1周的基线体重稳定期和（2）5周的TRF期。15名参与者完成了研究。评估了体重、体重指数（BMI）、腰臀比、骨骼肌质量、体脂肪量（BFM）、体脂百分比（BF%）、内脏脂肪面积（VFA）、促黄体生成素（LH）、促卵泡生成素（FSH）、LH/FSH、总睾酮（TT）、性激素结合球蛋白（SHBG）、游离雄激素指数（FAI）、空腹血糖、空腹胰岛素（FINS）、稳态模型评估胰岛素抵抗（HOMA-IR）、胰岛素曲线下面积（AUCIns）、葡萄糖曲线下面积（AUCGlu）、AUCIns/AUCGlu比值、血脂、尿酸、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶、高敏C反应蛋白（hsCRP）、胰岛素样生长因子（IGF-1）、月经周期和饮食行为的变化。
TRF期后，体重、BMI、BFM、BF%、VFA、TT、SHBG、FAI、FINS、HOMA-IR、AUCIns、AUCIns/AUCGlu比值、ALT、hsCRP和IGF-1有显著变化。73.3%（11/15）的患者月经周期不规律情况得到改善。
TRF饮食可能对无排卵性PCOS有益，尤其是在减肥方面，特别是减少体脂、改善月经、高雄激素血症、胰岛素抵抗和慢性炎症。试验注册Clinicaltrial.gov，NCT04580433，于2020年10月8日注册，https://clinicaltrials.gov/ct2/show/NCT04580433 。
