Bice D E, McCarron K, Hoffman E O, Salvaggio J
Int Arch Allergy Appl Immunol. 1977;55(1-6):267-74. doi: 10.1159/000231935.
The adjuvant properties of Micropolyspora faeni, an important source of antigenic material in the production of farmer's lung, were evaluated by comparing antibody- and cell-mediated immune responses of rabbits to bovine serum albumin (BSA) incorporated in complete Freund's adjuvant (CFA), incomplete Freund's adjuvant (IFA) and incomplete Freund's adjuvant with 5-10 mg/ml homogenized M. faeni (MFA). Rabbits immunized with BSA in CFA or MFA developed significantly increased antigen-induced macrophage migration inhibition, lymphocyte stimulation, and delayed skin reactivity when compared to those immunized with BSA in IFA. No similar adjuvant effect on specific antibody production was observed in rabbits immunized using BSA in MFA. These data suggest that M. faeni can act as a selective immunologic adjuvant for delayed hypersensitivity. This adjuvant property might be important in the induction of mononuclear cell infiltrates seen in human hypersensitivity pneumonitis.
通过比较兔对掺入完全弗氏佐剂（CFA）、不完全弗氏佐剂（IFA）以及含5 - 10毫克/毫升匀浆费氏小多孢菌（MFA）的不完全弗氏佐剂中的牛血清白蛋白（BSA）的抗体介导和细胞介导免疫反应，评估了费氏小多孢菌（农民肺生产中抗原物质的重要来源）的佐剂特性。与用IFA中的BSA免疫的兔子相比，用CFA或MFA中的BSA免疫的兔子抗原诱导的巨噬细胞迁移抑制、淋巴细胞刺激和迟发性皮肤反应性显著增加。在用MFA中的BSA免疫的兔子中未观察到对特异性抗体产生的类似佐剂作用。这些数据表明，费氏小多孢菌可作为迟发型超敏反应的选择性免疫佐剂。这种佐剂特性可能在人类过敏性肺炎中所见单核细胞浸润的诱导中起重要作用。
