Liu Dan, Gao Ya, Li Lingling, Chen He, Bai Lu, Qu Yanli, Zhou Baosen, Yan Ying, Zhao Yuxia
Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.
Department of Oncology, Kailuan Hospital, Tangshan, Hebei 063000, P.R. China.
Oncol Lett. 2021 May;21(5):424. doi: 10.3892/ol.2021.12685. Epub 2021 Mar 29.
BRCA1 is a tumor suppressor that has been found to be involved DNA synthesis during cell replication. In a recent study, the single nucleotide polymorphism (SNP), rs799917, in BRCA1 was found to be associated with the development and progression of various types of tumor. In the present study, the association between rs799917 and susceptibility to lung cancer was evaluated in a Han Chinese population in the Liaoning Province of China. The BRCA1 rs799917 genotypes (C/C, C/T and T/T) were analyzed using TaqMan quantitative PCR in 682 patients with lung cancer and 694 healthy controls, and the results were analyzed using a Student's t-test, a χ test and logistic regression analysis. Individuals carrying the C/T or T/T genotype had a lower risk of lung cancer compared with those carrying the C/C genotype [odds ratio (OR), 0.741; P=0.021; and OR, 0.610; P=0.011, respectively). The C/T + T/T genotype group had an even lower risk (OR, 0.709; P=0.005) compared with that in the C/C genotype group. In the stratified analyses of non-smokers, individuals with the C/T or T/T genotype had a lower risk of developing lung cancer compared with that in those carrying the C/C genotype (OR, 0.681; P=0.013; and OR, 0.569; P=0.021, respectively). The stratified analyses of the BRCA1 rs799917 polymorphism based on pathological type, chemotherapy and radiotherapy, showed that in the squamous cell carcinoma, non-chemotherapy and non-radiotherapy subgroups, individuals with the T/T genotype had a lower risk of lung cancer compared with that in those carrying the C/C genotype (OR, 0.454; P=0.007; OR, 0.485; P=0.002; and OR, 0.599; P=0.020, respectively). In conclusion, the T allele of the rs799917 SNP in BRCA1 was associated with a lower risk of lung cancer in the ethnic Han Chinese population in Liaoning Province and may represent a protective factor against lung cancer.
BRCA1是一种肿瘤抑制基因，已发现其在细胞复制过程中参与DNA合成。在最近的一项研究中，发现BRCA1中的单核苷酸多态性（SNP）rs799917与各种类型肿瘤的发生和发展有关。在本研究中，在中国辽宁省的汉族人群中评估了rs799917与肺癌易感性之间的关联。使用TaqMan定量PCR对682例肺癌患者和694例健康对照者的BRCA1 rs799917基因型（C/C、C/T和T/T）进行分析，并使用学生t检验、χ²检验和逻辑回归分析结果。与携带C/C基因型的个体相比，携带C/T或T/T基因型的个体患肺癌的风险较低[比值比（OR）分别为0.741；P = 0.021；以及OR为0.610；P = 0.011]。与C/C基因型组相比，C/T + T/T基因型组的风险更低（OR为0.709；P = 0.005）。在非吸烟者的分层分析中，与携带C/C基因型的个体相比，携带C/T或T/T基因型的个体患肺癌的风险较低（OR分别为0.681；P = 0.013；以及OR为0.569；P = 0.021）。基于病理类型、化疗和放疗对BRCA1 rs799917多态性进行的分层分析表明，在鳞状细胞癌、非化疗和非放疗亚组中，与携带C/C基因型的个体相比，携带T/T基因型的个体患肺癌的风险较低（OR分别为0.454；P = 0.007；OR为0.485；P = 0.002；以及OR为0.599；P = 0.020）。总之，BRCA1中rs799917 SNP的T等位基因与辽宁省汉族人群患肺癌的较低风险相关，可能是预防肺癌的一个保护因素。
