Björnström Agnes, Blomström Anne-Lie, Singh Manish Chandra, Hesson Jenny C
Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Sweden.
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, 750 07 Uppsala, Sweden.
One Health. 2021 Mar 25;12:100242. doi: 10.1016/j.onehlt.2021.100242. eCollection 2021 Jun.
A number of viruses transmitted by mosquitoes are well known to cause disease in both humans and horses, ranging from mild fevers to mortal neurological disease. A recently discovered connection between the alphavirus Sindbis virus (SINV) and neurological disease in horses in South Africa initiated this serological study in northern Europe, where the same genotype of SINV (SINV-I) is also highly endemic. We tested 171 serum samples, originally obtained from horses for other reasons from April to October 2019, for presence of SINV neutralising antibodies using a plaque reduction neutralisation test (PRNT). The serum from six horses reduced the plaque count more than 80%, and two out of these reduced the plaque count more than 90%. These horses were sampled in six different regions of Sweden, and included individuals sampled from April to August. This study shows that horses in Sweden have become infected with SINV and developed neutralising antibodies. Potential connections between infection and development of disease are important questions for future studies.
许多由蚊子传播的病毒都众所周知会在人类和马匹中引发疾病，从轻微发烧到致命的神经疾病不等。最近在南非发现的甲病毒辛德毕斯病毒（SINV）与马匹神经疾病之间的联系，促使了在北欧开展这项血清学研究，在北欧，相同基因型的SINV（SINV-I）也高度流行。我们使用蚀斑减少中和试验（PRNT）对171份血清样本进行检测，这些样本最初是在2019年4月至10月因其他原因从马匹身上采集的，以检测是否存在SINV中和抗体。六匹马的血清使蚀斑数量减少了80%以上，其中两匹马的血清使蚀斑数量减少了90%以上。这些马是在瑞典的六个不同地区采集的样本，包括4月至8月采集样本的个体。这项研究表明瑞典的马匹已感染SINV并产生了中和抗体。感染与疾病发展之间的潜在联系是未来研究的重要问题。
