Unité des Virus Emergents, UVE: Aix Marseille Université, IRD 190, Inserm 1207, AP-HM Hôpitaux Universitaires de Marseille, 13005 Marseille, France.
Laboratoire des Arbovirus et Virus Emergents, Institut Pasteur d'Algérie, Algiers 16096, Algeria.
Viruses. 2022 Apr 25;14(5):894. doi: 10.3390/v14050894.
Sindbis virus (SINV) is a zoonotic alphavirus (family , genus ) that causes human diseases in Africa, Europe, Asia, and Australia. Occasionally, SINV outbreaks were reported in South Africa and northern Europe. Birds are the main amplifying hosts of SINV, while mosquitoes play the role of the primary vector. mosquitoes were collected in Algeria and subsequently tested for SINV. SINV RNA was detected in 10 pools out of 40, from a total of 922 mosquitoes tested. A strain of SINV was isolated from a pool displaying high viral load. Whole-genome sequencing and phylogenetic analysis showed that the SINV Algeria isolate was most closely related to a Kenyan strain. This was the first record of SINV in Algeria and more broadly in northwestern Africa, which can be a potential risk for human health in the circulating area. Further studies are needed to measure the impact on public health through seroprevalence studies in Algeria.
辛德毕斯病毒（SINV）是一种动物源正呼肠孤病毒（科，属），可在非洲、欧洲、亚洲和澳大利亚引起人类疾病。偶尔在南非和北欧也有 SINV 爆发的报道。鸟类是 SINV 的主要扩增宿主，而蚊子则充当主要传播媒介。在阿尔及利亚收集了蚊子，并随后对其进行了 SINV 检测。在总共检测的 922 只蚊子中，有 10 个蚊群中检测到 SINV RNA。从一个病毒载量较高的蚊群中分离到一株 SINV。全基因组测序和系统发育分析表明，阿尔及利亚 SINV 分离株与肯尼亚株最为密切相关。这是 SINV 在阿尔及利亚乃至更广泛的西北非的首次记录，这可能是该流行地区对人类健康的潜在威胁。需要进一步研究通过在阿尔及利亚进行血清流行率研究来衡量对公共卫生的影响。
