Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.
Adv Biochem Eng Biotechnol. 2021;178:169-196. doi: 10.1007/10_2021_165.
The past few decades have witnessed the emergence of a variety of hydrogel materials for applications ranging from health to solutions for restoring natural environments. Among the numerous ways to synthesize these materials, directly assembling genetically engineered proteins into higher-order structures turned out to be a powerful strategy for hydrogel design. In recent years, the resulting genetically engineered (GE) hydrogels, noted for their modularity, versatility, and genetic programmability, are gaining traction with materials scientists and synthetic biologists who are eyeing the prospect of mass producing these materials via biosynthesis. In this chapter, we review the recent progresses in creating GE hydrogels, especially those enabled by self-assembling protein motifs, as well as their applications.
过去几十年见证了各种水凝胶材料的出现，这些材料的应用范围从健康到恢复自然环境的解决方案。在合成这些材料的众多方法中，直接将基因工程蛋白组装成高级结构被证明是一种用于水凝胶设计的强大策略。近年来，由此产生的基因工程（GE）水凝胶因其模块化、多功能性和遗传可编程性而受到材料科学家和合成生物学家的关注，他们希望通过生物合成大规模生产这些材料。在本章中，我们回顾了创建 GE 水凝胶的最新进展，特别是那些由自组装蛋白基序实现的水凝胶，以及它们的应用。
