氨基酸同源性研究的潜力：大肠杆菌β-半乳糖苷酶与乳糖阻遏物之间发现的同源性。

Potential of the amino acid homology studies: homologies found between beta-galactosidase and lac repressor of E. coli.

作者信息

Erhan S, Greller L D

出版信息

Int J Biomed Comput. 1977 Oct;8(4):283-91. doi: 10.1016/0020-7101(77)90068-x.

Abstract

Significant amino acid homologies were found between beta-galactosidase fragments and lac repressor of E. coli using a sliding match according to Greller and Erhan (1974). Since both of these proteins can recognise and bind galactose moiety, we propose that the homologous regions represetn galactose binding site(s) on both proteins. Possible application of homology studies to problems of protein and nucleic acid chemistry is also discussed.

摘要

根据格雷勒和埃尔汉（1974年）的方法，采用滑动匹配法发现β-半乳糖苷酶片段与大肠杆菌的乳糖阻遏物之间存在显著的氨基酸同源性。由于这两种蛋白质都能识别并结合半乳糖部分，我们提出同源区域代表了这两种蛋白质上的半乳糖结合位点。还讨论了同源性研究在蛋白质和核酸化学问题上的可能应用。